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. 2020 Feb 14;12(2):119.
doi: 10.3390/toxins12020119.

Methicillin-Resistant Staphylococcus aureus ST80 Clone: A Systematic Review

Assia Mairi  1 , Abdelaziz Touati  1 , Jean-Philippe Lavigne  2
Affiliations

Methicillin-Resistant Staphylococcus aureus ST80 Clone: A Systematic Review

Assia Mairi et al. Toxins (Basel). .

Abstract

This review assessed the molecular characterization of the methicillin-resistant Staphylococcus aureus (MRSA)-ST80 clone with an emphasis on its proportion of total MRSA strains isolated, PVL production, spa-typing, antibiotic resistance, and virulence. A systematic review of the literature was conducted on MRSA-ST80 clone published between 1 January 2000 and 31 August 2019. Citations were chosen for a review of the full text if we found evidence that MRSA-ST80 clone was reported in the study. For each isolate, the country of isolation, the sampling period, the source of isolation (the type of infection, nasal swabs, or extra-human), the total number of MRSA strains isolated, number of MRSA-ST80 strains, antibiotic resistance patterns, PVL production, virulence genes, and spa type were recorded. The data from 103 articles were abstracted into an Excel database. Analysis of the data showed that the overall proportion of MRSA-ST80 has been decreasing in many countries in recent years. The majority of MRSA-ST80 were PVL positive with spa-type t044. Only six reports of MRSA-ST80 in extra-human niches were found. This review summarizes the rise of MRSA-ST80 and the evidence that suggests that it could be in decline in many countries.

Keywords: MRSA; Panton–Valentine leukocidin; ST80 clone; decline; epidemic; extra-human; human; worldwide diffusion.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Prevalence of the methicillin-resistant Staphylococcus aureus (MRSA)-ST80 clone in Asia.
Figure 2
Figure 2
Prevalence of the MRSA-ST80 clone in North Africa.
Figure 3
Figure 3
Prevalence of the MRSA-ST80 clone in the Middle East.
Figure 4
Figure 4
Prevalence of the MRSA-ST80 clone in Europe.
See this image and copyright information in PMC

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