MerTK Blockade Fuels Anti-tumor Immunity

J Magarian Blander¹

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¹ The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Sandra and Edward Meyer Cancer Center, Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA. Electronic address: jmblander@med.cornell.edu.

PMID: 32075723
DOI: 10.1016/j.immuni.2020.01.015

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MerTK Blockade Fuels Anti-tumor Immunity

J Magarian Blander. Immunity. 2020.

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. 2020 Feb 18;52(2):212-214.

doi: 10.1016/j.immuni.2020.01.015.

Author

J Magarian Blander¹

Affiliation

¹ The Jill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Sandra and Edward Meyer Cancer Center, Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA. Electronic address: jmblander@med.cornell.edu.

PMID: 32075723
DOI: 10.1016/j.immuni.2020.01.015

Abstract

Phagocytosis of apoptotic cells via the receptor MerTK is important for immune tolerance. In this issue of Immunity, Zhou et al. report that blockade of MerTK-mediated phagocytosis mobilizes anti-tumor immunity through a mechanism that involves the transport of tumor-derived cGAMP into macrophages via the ATP-activated channel P2X7R.

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Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP.
Zhou Y, Fei M, Zhang G, Liang WC, Lin W, Wu Y, Piskol R, Ridgway J, McNamara E, Huang H, Zhang J, Oh J, Patel JM, Jakubiak D, Lau J, Blackwood B, Bravo DD, Shi Y, Wang J, Hu HM, Lee WP, Jesudason R, Sangaraju D, Modrusan Z, Anderson KR, Warming S, Roose-Girma M, Yan M. Zhou Y, et al. Immunity. 2020 Feb 18;52(2):357-373.e9. doi: 10.1016/j.immuni.2020.01.014. Epub 2020 Feb 11. Immunity. 2020. PMID: 32049051

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MerTK Blockade Fuels Anti-tumor Immunity

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MerTK Blockade Fuels Anti-tumor Immunity

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