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Comparative Study
. 2020 Feb 19;10(1):2983.
doi: 10.1038/s41598-020-59830-6.

Characteristics and outcomes of bacteremia among ICU-admitted patients with severe sepsis

Akira Komori  1 , Toshikazu Abe  2   3   4 , Shigeki Kushimoto  5 , Hiroshi Ogura  6 , Atsushi Shiraishi  7 , Daizoh Saitoh  8 , Seitaro Fujishima  9 , Toshihiko Mayumi  10 , Toshio Naito  1 , Toru Hifumi  11 , Yasukazu Shiino  12 , Taka-Aki Nakada  13 , Takehiko Tarui  14 , Yasuhiro Otomo  15 , Kohji Okamoto  16 , Yutaka Umemura  6 , Joji Kotani  17 , Yuichiro Sakamoto  18 , Junichi Sasaki  19 , Shin-Ichiro Shiraishi  20 , Kiyotsugu Takuma  21 , Ryosuke Tsuruta  22 , Akiyoshi Hagiwara  23 , Kazuma Yamakawa  24 , Tomohiko Masuno  25 , Naoshi Takeyama  26 , Norio Yamashita  27 , Hiroto Ikeda  28 , Masashi Ueyama  29 , Satoshi Fujimi  24 , Satoshi Gando  30   31 ; JAAM FORECAST group
Collaborators, Affiliations
Comparative Study

Characteristics and outcomes of bacteremia among ICU-admitted patients with severe sepsis

Akira Komori et al. Sci Rep. .

Abstract

The clinical implications of bacteremia among septic patients remain unclear, although a vast amount of data have been accumulated on sepsis. We aimed to compare the clinical characteristics and outcomes of severe sepsis patients with and without bacteremia. This secondary analysis of a multicenter, prospective cohort study included 59 intensive care units (ICUs) in Japan between January 2016 and March 2017. The study cohort comprised 1,184 adults (aged ≥ 16 years) who were admitted to an ICU with severe sepsis and diagnosed according to the Sepsis-2 criteria. Of 1,167 patients included in the analysis, 636 (54.5%) had bacteremia. Those with bacteremia had significantly higher rates of septic shock (66.4% vs. 58.9%, p = 0.01) and higher sepsis severity scores, including the Acute Physiology and Chronic Health Evaluation (APACHE) II and the Sequential Organ Failure Assessment (SOFA). No significant difference in in-hospital mortality was seen between patients with and without bacteremia (25.6% vs. 21.0%, p = 0.08). In conclusion, half of severe sepsis patients in ICUs have bacteremia. Although patients with bacteremia had more severe state, between-group differences in patient-centered outcomes, such as in-hospital mortality, have not been fully elucidated.

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Conflict of interest statement

The authors declare no competing interests.

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