Could stress ulcer prophylaxis increase mortality in high-acuity patients?

Michael O Harhay^{1

2}, Paul J Young^{3

4}, Manu Shankar-Hari^{5

6}

Affiliations

¹ Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, 304 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104-6021, USA. mharhay@pennmedicine.upenn.edu.
² Palliative and Advanced Illness Research (PAIR) Center and Pulmonary and Critical Care Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mharhay@pennmedicine.upenn.edu.
³ Medical Research Institute of New Zealand, Wellington, New Zealand.
⁴ Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.
⁵ Guy's and St. Thomas' NHS Foundation Trust, ICU Support Offices, St. Thomas' Hospital, London, UK.
⁶ School of Immunology and Microbial Sciences, Kings College London, London, UK.

Editorial

Michael O Harhay et al. Intensive Care Med. 2020 Apr.

. 2020 Apr;46(4):793-795.

doi: 10.1007/s00134-020-05959-x. Epub 2020 Feb 19.

Michael O Harhay^{1

2}, Paul J Young^{3

4}, Manu Shankar-Hari^{5

6}

¹ Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, 304 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104-6021, USA. mharhay@pennmedicine.upenn.edu.
² Palliative and Advanced Illness Research (PAIR) Center and Pulmonary and Critical Care Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mharhay@pennmedicine.upenn.edu.
³ Medical Research Institute of New Zealand, Wellington, New Zealand.
⁴ Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.
⁵ Guy's and St. Thomas' NHS Foundation Trust, ICU Support Offices, St. Thomas' Hospital, London, UK.
⁶ School of Immunology and Microbial Sciences, Kings College London, London, UK.

No abstract available

Comment on

Heterogeneity of treatment effect of prophylactic pantoprazole in adult ICU patients: a post hoc analysis of the SUP-ICU trial.
Granholm A, Marker S, Krag M, Zampieri FG, Thorsen-Meyer HC, Kaas-Hansen BS, van der Horst ICC, Lange T, Wetterslev J, Perner A, Møller MH. Granholm A, et al. Intensive Care Med. 2020 Apr;46(4):717-726. doi: 10.1007/s00134-019-05903-8. Epub 2020 Jan 14. Intensive Care Med. 2020. PMID: 31938829