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. 2020 Apr;99(4):799-808.
doi: 10.1007/s00277-020-03918-6. Epub 2020 Feb 20.

RELINF: prospective epidemiological registry of lymphoid neoplasms in Spain. A project from the GELTAMO group

Mariana Bastos-Oreiro  1   2 , Ana Muntañola  3 , Carlos Panizo  4 , Eva Gonzalez-Barca  5 , Sonia González de Villambrosia  6 , Raúl Córdoba  7 , Jose Luís Bello López  8 , Pedro González-Sierra  9 , María José Terol  10 , Antonio Gutierrez  11 , Carlos Grande  12 , María José Ramirez  13 , Laura Iserte  14 , Elena Perez  15 , Belén Navarro  16 , Pilar Gomez  17 , Antonio Salar  18 , Hugo Luzardo  19 , Andrés López  20 , Raquel Del Campo  21 , Daniel García-Belmonte  22 , María Jesús Vida  23 , María Infante  24 , Jose Antonio Queizan-Hernandez  25 , Silvana Novelli  26 , Miriam Moreno  27 , Miriam Penarrubia  28 , Joaquín Gómez  29 , Abel Domingo  30 , Eva Donato  31 , María Cruz Viguria  32 , Francisca López  33 , María José Rodriguez  34 , Emilia Pardal  35 , Victor Noriega  36 , Rafael Andreu  37 , Javier Peñalver  38 , Alejandro Martín  39 , Dolores Caballero  39 , Armando López-Guillermo  40
Affiliations

RELINF: prospective epidemiological registry of lymphoid neoplasms in Spain. A project from the GELTAMO group

Mariana Bastos-Oreiro et al. Ann Hematol. 2020 Apr.

Abstract

Lymphomas are a large, heterogeneous group of neoplasms with well-defined characteristics, and this heterogeneity highlights the importance of epidemiological data. Knowledge of local epidemiology is essential to optimise resources, design clinical trials, and identify minority entities. Given there are few published epidemiological data on lymphoma in Spain, the Spanish Lymphoma and Autologous Bone Marrow Transplant Group created the RELINF project. The aim of this project is to determine the frequencies and distribution of lymphoid neoplasms in Spain and to analyse survival. We developed an online platform for the prospective collection of data on newly diagnosed cases of lymphoma in Spain between January 2014 and July 2018; 11,400 patients were registered. Diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL) were the most frequent lymphomas in our series. Marginal B cell lymphoma frequency was higher than that reported in other studies, representing more than 11% of mature B cell lymphomas. Peripheral T cell lymphoma not otherwise specified (PTCL-NOS) was the most common subtype of T cell lymphoma, and NK/T cell lymphomas were more frequent than expected (5.4% of total). Hodgkin's lymphoma accounted for 12% of lymphoproliferative syndromes. Overall survival was greater than 90% at 2 years for indolent B cell lymphomas, and approximately 60% for DLBCL, somewhat lower than that previously reported. Survival was poor for PTCL-NOS and angioimmunoblastic T cell lymphoma, as expected; however, it was somewhat better than that in other studies for anaplastic large cell anaplastic lymphoma kinase lymphomas. This is the first prospective registry to report the frequencies, distribution, and survival of lymphomas in Spain. The frequencies and survival data we report here are globally consistent with that reported in other Western countries. These updated frequencies and survival statistics are necessary for developing appropriate management strategies for neoplasias in the Spanish population.

Keywords: Epidemiology; Frequencies; Lymphoma; Survival.

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