Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2020 Feb;12(1):31-37.
doi: 10.1111/os.12608.

Influence of Ketorolac Supplementation on Pain Control for Knee Arthroscopy: A Meta-Analysis of Randomized Controlled Trials

Rui-Jie Wan  1   2 , Shao-Fan Liu  2 , Zhi-Ping Kuang  1   2 , Qiang Ran  2 , Chen Zhao  1 , Wei Huang  1
Affiliations
Meta-Analysis

Influence of Ketorolac Supplementation on Pain Control for Knee Arthroscopy: A Meta-Analysis of Randomized Controlled Trials

Rui-Jie Wan et al. Orthop Surg. 2020 Feb.

Abstract

Introduction: The efficacy of ketorolac supplementation on pain control for knee arthroscopy remains controversial. We conduct a systematic review and meta-analysis to explore the impact of ketorolac supplementation on pain intensity after knee arthroscopy.

Methods: We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through September 2018 for randomized controlled trials (RCTs) assessing the effect of ketorolac supplementation vs placebo on pain management after knee arthroscopy. This meta-analysis is performed using the random-effect model.

Results: Ten RCTs involving 402 patients are included in the meta-analysis. Overall, compared with control group for knee arthroscopy, ketorolac supplementation is associated with notably reduced pain scores at 1 h (MD = -0.66; 95% CI = -1.12 to -0.21; P = 0.004) and 2 h (MD = -0.90; 95% CI = -1.74 to -0.07; P = 0.03), prolonged time for first analgesic requirement (MD = 1.94; 95% CI = 0.33 to 3.55; P = 0.02) and decreased number of analgesic requirement (RR = 0.41; 95% CI = 0.23 to 0.75; P = 0.003), but has no obvious impact on analgesic consumption (MD = -0.56; 95% CI = -1.14 to 0.02; P = 0.06), as well as nausea and vomiting (RR = 0.44; 95% CI = 0.12 to 0.21; P = 0.21).

Conclusions: Ketorolac supplementation is effective to produce pain relief for knee arthroscopy.

Keywords: ketorolac supplementation; knee arthroscopy; meta-analysis; pain control; randomized controlled trials.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow diagram of study searching and selection process.
Figure 2
Figure 2
Forest plot for the meta‐analysis of pain scores at 1 h.
Figure 3
Figure 3
Forest plot for the meta‐analysis of pain scores at 2 h.
Figure 4
Figure 4
Forest plot for the meta‐analysis of time for first analgesic requirement (min).
Figure 5
Figure 5
Forest plot for the meta‐analysis of number of analgesic requirement.
Figure 6
Figure 6
Forest plot for the meta‐analysis of analgesic consumption.
Figure 7
Figure 7
Forest plot for the meta‐analysis of nausea and vomiting.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Wojahn RD, Bogunovic L, Brophy RH, et al Opioid consumption after knee arthroscopy. J Bone Joint Surg Am, 2018, 100: 1629–1636. - PubMed
    1. Howard DH. Trends in the use of knee arthroscopy in adults. JAMA Intern Med, 2018, 178: 1557–1558. - PMC - PubMed
    1. Jarvinen TL, Sihvonen R, Englund M. Arthroscopy for degenerative knee—a difficult habit to break?. Acta Orthop, 2014, 85: 215–217. - PMC - PubMed
    1. Drosos GI, Stavropoulos NI, Katsis A, Kesidis K, Kazakos K, Verettas DA. Post‐operative pain after knee arthroscopy and related factors. Open Orthop J, 2008, 2: 110–114. - PMC - PubMed
    1. Jacobson E, Forssblad M, Weidenhielm L, Renstrom P. Knee arthroscopy with the use of local anesthesia—an increased risk for repeat arthroscopy? A prospective, randomized study with a six‐month follow‐up. Am J Sports Med, 2002, 30: 61–65. - PubMed

MeSH terms

Substances