Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Dec;92(12):2938-2945.
doi: 10.1002/jmv.25717. Epub 2020 Feb 29.

A lesson learnt from the emergence of Zika virus: What flaviviruses can trigger Guillain-Barré syndrome?

Char Leung  1
Affiliations

A lesson learnt from the emergence of Zika virus: What flaviviruses can trigger Guillain-Barré syndrome?

Char Leung. J Med Virol. 2020 Dec.

Abstract

While Zika virus outbreaks raised the concern about rare viral infections in human, attention should also be paid to other Guillain-Barré syndrome (GBS) inducing viruses. This study aims to search for other flaviviruses likely to be associated with GBS. Amino acid (aa) sequence matching analysis was conducted to identify viruses molecularly similar to the Zika virus and human GBS-related proteins. A systematic review of clinical literature was performed to summarize the clinical findings of the GBS-associated flaviviruses identified in the aa sequence matching analysis. It was found that more than 10 pentapeptides were shared between 9 flaviviruses, Zika virus, and human GBS-related proteins. Twenty-six articles totaling 42 clinical cases were eligible for inclusion in the systematic review concerning the nine flaviviruses identified. While some patients showed signs of encephalitis, 5 out of 42 cases demonstrated typical GBS symptoms. Public health professionals should be aware of other GBS-associated flaviviruses and GBS cases with mild symptoms.

Keywords: Guillain-Barré syndrome; Zika virus; amino acid sequence matching; flavivirus.

PubMed Disclaimer

References

REFERENCES

    1. Cao-Lormeau VM, Blake A, Mons S, et al. Guillain-Barré syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet. 2016;387(10027):1531-1539. https://doi.org/10.1016/S0140-6736(16)00562-6
    1. Garg M. Respiratory involvement in Guillain-Barre syndrome: the uncharted road to recovery. J Neurosci Rural Pract. 2017;8(3):325-326. https://doi.org/10.4103/jnrp.jnrp_96_17R1
    1. Leonhard SE, Mandarakas MR, Gondim FAA, et al. Diagnosis and management of Guillain-Barré syndrome in ten steps. Nat Rev Neurol. 2019;15(11):671-683. https://doi.org/10.1038/s41582-019-0250-9
    1. Sudulagunta SR, Sodalagunta MB, Sepehrar M, et al. Guillain-Barré syndrome: clinical profile and management. Ger Med Sci. 2015;13:Doc16. https://doi.org/10.3205/000220
    1. Ansari B, Basiri K, Derakhshan Y, Kadkhodaei F, Okhovat AA. Epidemiology and clinical features of Guillain-Barre syndrome in Isfahan, Iran. Adv Biomed Res. 2018;7:87. https://doi.org/10.4103/abr.abr_50_17

Publication types

LinkOut - more resources