Incorrect Analyses of Cluster-Randomized Trials that Do Not Take Clustering and Nesting into Account Likely Lead to p-Values that Are Too Small
- PMID: 32078372
- PMCID: PMC7047086
- DOI: 10.1089/chi.2019.0142
Incorrect Analyses of Cluster-Randomized Trials that Do Not Take Clustering and Nesting into Account Likely Lead to p-Values that Are Too Small
Conflict of interest statement
D.B.A. reports grants from NIH, outside the submitted work, and D.B.A. has received personal payments or promises for same from American Society for Nutrition; American Statistical Association; Biofortis; Columbia University; Fish & Richardson, P.C.; Frontiers Publishing; Henry Stewart Talks; IKEA; Indiana University; Laura and John Arnold Foundation; Johns Hopkins University; Law Offices of Ronald Marron; MD Anderson Cancer Center; Medical College of Wisconsin; NIH; Sage Publishing; The Obesity Society; Tomasik, Kotin & Kasserman LLC; University of Alabama at Birmingham; University of Miami; Nestle; and WW (formerly Weight Watchers International, LLC). Donations to a foundation have been made on his behalf by the Northarvest Bean Growers Association. D.B.A. is an unpaid member of the International Life Sciences Institute North America Board of Trustees. D.B.A.'s institution, Indiana University, has received funds to support his research or educational activities from NIH; Alliance for Potato Research and Education; American Federation for Aging Research; Dairy Management, Inc.; Herbalife; Laura and John Arnold Foundation; and Oxford University Press. D.B.A.'s prior institution, the University of Alabama at Birmingham, received gifts, contracts, and grants from the Coca-Cola Company, Pepsi, and Dr. Pepper/Snapple. In the past 12 months, Dr. Brown has received travel expenses from University of Louisville; speaking fees from Kentuckiana Health Collaborative, and Rippe Lifestyle Institute, Inc.; and he has been involved in research for which his institution or colleagues have received grants from Dairy Management, Inc., NIH, and the Sloan Foundation. The other authors declare that they have no conflict of interest.
Comment in
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Response to: Comment About Statistical Analysis of a Cluster-Randomized Trial About Clustering and Nesting (DOI: 10.1089/chi.2019.0142).Child Obes. 2020 Mar;16(2):67-69. doi: 10.1089/chi.2019.0265. Child Obes. 2020. PMID: 32078371 No abstract available.
Comment on
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A School-Based, Peer-Led, Social Marketing Intervention To Engage Spanish Adolescents in a Healthy Lifestyle ("We Are Cool"-Som la Pera Study): A Parallel-Cluster Randomized Controlled Study.Child Obes. 2017 Aug;13(4):300-313. doi: 10.1089/chi.2016.0216. Epub 2017 Apr 27. Child Obes. 2017. Retraction in: Child Obes. 2020 Oct;16(7):544-545. doi: 10.1089/chi.2016.0216.retract. PMID: 28448174 Retracted. Clinical Trial.
References
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- Aceves-Martins M, Llauradó E, Tarro L, et al. . A school-based, peer-led, social marketing intervention to engage spanish adolescents in a healthy lifestyle (“We Are Cool”—Som la Pera Study): A parallel-cluster randomized controlled study. Child Obes 2017;13:300–313 - PubMed
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- Casazza K, Allison DB. Stagnation in the clinical, community and public health domain of obesity: The need for probative research. Clin Obes 2012;2:83–85 - PubMed
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- ClinicalTrials.gov Identifier: NCT02157402. EYTO (European Youth Tackling Obesity): A Randomized Controlled Trial in Catalonia (Spain) (EYTO-SPAIN). [Clinical trial]. 2014. Available at https://clinicaltrials.gov/ct2/show/NCT02157402 Last accessed June4, 2019
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