Can the VTA Come Out to Play? Only When the mPFC's Predictions Go Astray!

Alexandra Stolyarova¹, Andrew M Wikenheiser²

Affiliations

¹ Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
² Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA; The Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: amwikenheiser@psych.ucla.edu.

PMID: 32078792
DOI: 10.1016/j.neuron.2020.01.036

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Can the VTA Come Out to Play? Only When the mPFC's Predictions Go Astray!

Alexandra Stolyarova et al. Neuron. 2020.

Free article

. 2020 Feb 19;105(4):593-595.

doi: 10.1016/j.neuron.2020.01.036.

Authors

Alexandra Stolyarova¹, Andrew M Wikenheiser²

Affiliations

¹ Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
² Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA; The Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: amwikenheiser@psych.ucla.edu.

PMID: 32078792
DOI: 10.1016/j.neuron.2020.01.036

Abstract

Confidence in perceptual decisions scales neural responses to violations in reward expectation. In this issue of Neuron, Lak et al. (2020) show that the medial prefrontal cortex in mice computes a confidence-dependent expectation signal that influences how dopamine neurons convey reward prediction errors to guide learning.

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Dopaminergic and Prefrontal Basis of Learning from Sensory Confidence and Reward Value.
Lak A, Okun M, Moss MM, Gurnani H, Farrell K, Wells MJ, Reddy CB, Kepecs A, Harris KD, Carandini M. Lak A, et al. Neuron. 2020 Feb 19;105(4):700-711.e6. doi: 10.1016/j.neuron.2019.11.018. Epub 2019 Dec 16. Neuron. 2020. PMID: 31859030 Free PMC article.

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Can the VTA Come Out to Play? Only When the mPFC's Predictions Go Astray!

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Can the VTA Come Out to Play? Only When the mPFC's Predictions Go Astray!

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