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Review
. 2020 Feb 16;21(4):1328.
doi: 10.3390/ijms21041328.

Platelet Concentrates in Musculoskeletal Medicine

Erminia Mariani  1   2 , Lia Pulsatelli  1
Affiliations
Review

Platelet Concentrates in Musculoskeletal Medicine

Erminia Mariani et al. Int J Mol Sci. .

Abstract

Platelet concentrates (PCs), mostly represented by platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are autologous biological blood-derived products that may combine plasma/platelet-derived bioactive components, together with fibrin-forming protein able to create a natural three-dimensional scaffold. These types of products are safely used in clinical applications due to the autologous-derived source and the minimally invasive application procedure. In this narrative review, we focus on three main topics concerning the use of platelet concentrate for treating musculoskeletal conditions: (a) the different procedures to prepare PCs, (b) the composition of PCs that is related to the type of methodological procedure adopted and (c) the clinical application in musculoskeletal medicine, efficacy and main limits of the different studies.

Keywords: composition; musculoskeletal diseases; platelet-rich fibrin; platelet-rich plasma; preparation.

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Conflict of interest statement

The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

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