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Randomized Controlled Trial
. 2020 Feb 25;75(7):835-837.
doi: 10.1016/j.jacc.2019.12.022.

Muscle Complaints or Events in Patients Randomized to Simvastatin or Ezetimibe/Simvastatin

Michael G Nanna, Ann Marie Navar, Robert P Giugliano, Jennifer A White, Yuliya Lokhnygina, Yale B Mitchel, Thomas A Musliner, Christopher P Cannon, Michael A Blazing
Randomized Controlled Trial

Muscle Complaints or Events in Patients Randomized to Simvastatin or Ezetimibe/Simvastatin

Michael G Nanna et al. J Am Coll Cardiol. .
No abstract available

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Figures

Figure 1.
Figure 1.. Kaplan-Meier Estimates of Time to First Muscle Complaint by Treatment Arm at 84 Months.
Treatment effect was non-proportional over time for muscle complaints. The solid black line denotes censoring at 50 months, which corrected the non-proportionality of treatment. Time to first muscle complaint remained similar between treatment groups (log-rank p-value = 0.09).
See this image and copyright information in PMC

References

    1. Navar AM. Fear-Based Medical Misinformation and Disease Prevention: From Vaccines to Statins. JAMA Cardiol. 2019; 8:723–724. - PubMed
    1. Cannon CP, Blazing MA, Giugliano RP et al. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. N Engl J Med 2015;372:2387–97. - PubMed
    1. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002;360(9326):7–22. - PubMed
    1. Baigent C, Landray MJ, Reith C, Emberson J, Wheeler DC, Tomson C, et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. Lancet. 2011;377(9784):2181–92. - PMC - PubMed

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