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Review
. 2020 Apr:33:36-44.
doi: 10.1016/j.euroneuro.2020.01.018. Epub 2020 Feb 18.

The brief negative symptom scale in translation: A review of psychometric properties and beyond

Affiliations
Review

The brief negative symptom scale in translation: A review of psychometric properties and beyond

Kazunori Tatsumi et al. Eur Neuropsychopharmacol. 2020 Apr.

Abstract

Negative symptoms are a core feature of schizophrenia and associated with social and occupational impairment. To encourage treatment development and address the limitations of existing rating instruments in this area across culture, the Brief Negative Symptoms Scale (BNSS) was developed. The authors reviewed studies published since the BNSS was published in 2010 that examined the psychometric properties of the instrument in translation and compared for consistency, psychometric performance and related features. Eleven published cross-cultural validation studies demonstrated the translated versions of the BNSS have strong psychometric properties, similar to the original English version. The internal consistency ranged from 0.88 to 0.98 and the inter-rater reliability ranged from 0.81 to 0.98 for the total score. The BNSS exhibited good convergent validity with existing measures of similar constructs and function, and good discriminant validity relative to other constructs. Recent research also reported that the BNSS is sensitive to drug effects, with effect sizes comparable to established scales. The results of confirmatory factor analyses revealed that the 5-factor structure of negative symptoms in schizophrenia (blunted affect, anhedonia, avolition, asociality, and alogia) crosses cultures. This psychometric evidence suggests that the BNSS is a valid and reliable instrument for assessing pathological mechanism underlying the negative symptoms of schizophrenia across cultures and can be a useful instrument in global clinical trials.

Keywords: BNSS; Cross-culture; Negative symptoms; Psychometrics; Schizophrenia; Translation.

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Conflict of interest statement

Conflict of interest Kazunori Tatsumi and Dr. Mark Opler are employees of WCG MedAvante-ProPhase LLC, New York, NY, which is licensed to provide the BNSS and provides training on its use. Dr. Kirkpatrick and Dr. Strauss receive licensing royalties and travel support from WCG MedAvante-ProPhase for use of the Brief Negative Symptom Scale (BNSS) by for-profit groups; these fees are donated the Brain and behavior Research Foundation. Dr. Kirkpatrick has also received consulting fees and travel support from Genentech/Roche, from WCG MedAvante-ProPhase LLC, consulting fees from anonymized pharmaceutical companies through Decision Resources, Inc. and from an investment capital company through Guideposts. Dr. Kirkpatrick also receives fees from Walsh Medical Media for editorial services, and received fees for editorial services from Physicians Postgraduate Press, Inc. Dr. Strauss has consulted or received speaking honorarium from Minerva Neurosciences, Lundbeck, and Acadia. There are no other conflicts of interest to report.

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