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Review
. 2019 Dec;73(6):421-424.
doi: 10.5455/medarh.2019.73.421-424.

A Brief Review of the Degenerative Intervertebral Disc Disease

Natasa Kos  1   2 , Lidija Gradisnik  2   3 , Tomaz Velnar  2   4
Affiliations
Review

A Brief Review of the Degenerative Intervertebral Disc Disease

Natasa Kos et al. Med Arch. 2019 Dec.

Abstract

Introduction: The degenerative processes of the intervertebral disc represent an important cause of morbidity in everyday clinical practice, exerting burden on patients and clinicians treating them. Numerous factors may initiate degenerative processes, which most commonly affect the nucleus pulposus and ultimately influence the biomechanics of the whole spine.

Aim: This paper provides an overview from the literature about the process, causes and mechanisms of disc degeneration and the associated factors.

Methods: The scientific literature was reviewed through PubMed, Medline and Science Direct. The articles were chosen in correlation with the study objective and their scientific relevance.

Results: Many mechanical factors, such as mechanical, traumatic, genetic and nutritional, may affect the integrity of the intervertebral disc. The degenerative processes involve the structural damage of the intervertebral disc and the changes in number and composition of cells. The main factor in the degeneration of the intervertebral disc is the loss of proteoglycans. Degenerative changes of the disc are connected to damage of adjacent structures, leading to functional changes, higher susceptibility to injuries and clinical signs and symptoms.

Conclusions: Degenerative disease of the intervertebral disc remains a significant health problem. Besides standard conservative and surgical treatment, techniques of regenerative therapy are becoming very promising, although still in the experimental phase.

Keywords: degenerative disease; fibrous annulus; intervertebral disc; nucleus pulposus; spine.

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Conflict of interest statement

There are no conflicts of interest.

References

    1. Hall JA, Konstantinou K, Lewis M, Oppong R, Ogollah R, Jowett S. Systematic Review of Decision Analytic Modelling in Economic Evaluations of Low Back Pain and Sciatica. Appl Health Econ Health Policy. 2019;17(4):467–491. - PubMed
    1. Cheung KM, Karppinen J, Chan D, Ho DW, Song YQ, Sham P, et al. Prevalence and pattern of lumbar magnetic resonance imaging changes in a population study of one thousand forty- three individuals. Spine. 2009;34(9):934–940. - PubMed
    1. Kanayama M, Togawa D, Takahashi C, Terai T, Hashimoto T. Cross-sectional magnetic resonance imaging study of lumbar disc degeneration in 200 healthy individuals. J Neurosurg Spine. 2009;11(4):501–507. - PubMed
    1. Cheung KM, Orlansky AS, Sen K, Elliot DM. Reduced nucleus pulposus glycosaminoglycan content alters intervertebral disc dynamic viscoelastic mechanics. J Biomech. 2009;42(12):1941–1946. - PMC - PubMed
    1. Colombini A, Lombardi G, Corsi MM, Banfi G. Pathophysiology of the human intervertebral disc. Int J Biochem Cell Biol. 2008;40(5):837–842. - PubMed

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