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Review
. 2020 Jan 30:12:9.
doi: 10.3389/fnagi.2020.00009. eCollection 2020.

Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives

Lina Ma  1
Affiliations
Review

Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives

Lina Ma. Front Aging Neurosci. .

Abstract

Objective: Mild cognitive impairment (MCI) is an important risk state for dementia, particularly Alzheimer's disease (AD). Depression, anxiety, and apathy are commonly observed neuropsychiatric features in MCI, which have been linked to cognitive and functional decline in daily activities, as well as disease progression. Accordingly, the study's objective is to review the prevalence, neuropsychological characteristics, and conversion rates to dementia between MCI patients with and without depression, anxiety, and apathy. Methods: A PubMed search and critical review were performed relating to studies of MCI, depression, anxiety, and apathy. Results: MCI patients have a high prevalence of depression/anxiety/apathy; furthermore, patients with MCI and concomitant depression/anxiety/apathy have more pronounced cognitive deficits and progress more often to dementia than MCI patients without depression/anxiety/apathy. Conclusions and Implications: Depression, anxiety, and apathy are common in MCI and represent possible risk factors for cognitive decline and progression to dementia. Further studies are needed to better understand the role and neurobiology of depression, anxiety, and apathy in MCI.

Keywords: anxiety; apathy; dementia; depression; mild cognitive impairment.

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References

    1. Aalten P., Verhey F. R. J., Boziki M., Bullock R., Byrne E. J., Camus V., et al. . (2007). Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: part I. Dement. Geriatr. Cogn. Disord. 24, 457–463. 10.1159/000110738 - DOI - PubMed
    1. Adams K. B. (2001). Depressive symptoms, depletion, or developmental change? Withdrawal, apathy, and lack of vigor in the geriatric depression scale. Gerontologist 41, 768–777. 10.1093/geront/41.6.768 - DOI - PubMed
    1. Apostolova L. G., Cummings J. L. (2008). Neuropsychiatric manifestations in mild cognitive impairment: a systematic review of the literature. Dement. Geriatr. Cogn. Disord. 25, 115–126. 10.1159/000112509 - DOI - PubMed
    1. Arbus C., Hergueta T., Duburcq A., Saleh A., Le Guern M. E., Robert P., et al. . (2014). Adjustment disorder with anxiety in old age: comparing prevalence and clinical management in primary care and mental health care. Eur. Psychiatry 29, 233–238. 10.1016/j.eurpsy.2013.04.002 - DOI - PubMed
    1. Basso M. R., Lowery N., Ghormley C., Combs D., Purdie R., Neel J., et al. . (2007). Comorbid anxiety corresponds with neuropsychological dysfunction in unipolar depression. Cogn. Neuropsychiatry 12, 437–456. 10.1080/13546800701446517 - DOI - PubMed