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Review
. 2020 Jan 30:11:24.
doi: 10.3389/fimmu.2020.00024. eCollection 2020.

Long Non-Coding RNAs Link Oxidized Low-Density Lipoprotein With the Inflammatory Response of Macrophages in Atherogenesis

Youyou Yan  1   2 , Dandan Song  3 , Junduo Wu  1 , Junnan Wang  1
Affiliations
Review

Long Non-Coding RNAs Link Oxidized Low-Density Lipoprotein With the Inflammatory Response of Macrophages in Atherogenesis

Youyou Yan et al. Front Immunol. .

Abstract

Atherosclerosis is characterized as a chronic inflammatory response to cholesterol deposition in arteries. Low-density lipoprotein (LDL), especially the oxidized form (ox-LDL), plays a crucial role in the occurrence and development of atherosclerosis by inducing endothelial cell (EC) dysfunction, attracting monocyte-derived macrophages, and promoting chronic inflammation. However, the mechanisms linking cholesterol accumulation with inflammation in macrophage foam cells are poorly understood. Long non-coding RNAs (lncRNAs) are a group of non-protein-coding RNAs longer than 200 nucleotides and are found to regulate the progress of atherosclerosis. Recently, many lncRNAs interfering with cholesterol deposition or inflammation were identified, which might help elucidate their underlying molecular mechanism or be used as novel therapeutic targets. In this review, we summarize and highlight the role of lncRNAs linking cholesterol (mainly ox-LDL) accumulation with inflammation in macrophages during the process of atherosclerosis.

Keywords: atherosclerosis; cholesterol accumulation; inflammation; lncRNAs; ox-LDL.

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Figures

Figure 1
Figure 1
The mechanism of lncRNA in high fat diet or Ox-LDL induced atheroslerosis.
See this image and copyright information in PMC

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