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. 2020 Jan;32(108):35-41.
doi: 10.22038/ijorl.2019.31926.2050.

Correlation of Serum Vitamin D Levels with Chronic Rhinosinusitis Disease Severity

Vahid Zand  1 , Mohammadhossein Baradaranfar  1 , Sedighe Vaziribozorg  1 , Mohammad Mandegari  2 , Mahzad Mansourimanesh  1 , Nasir Saeidieslami  1   2
Affiliations

Correlation of Serum Vitamin D Levels with Chronic Rhinosinusitis Disease Severity

Vahid Zand et al. Iran J Otorhinolaryngol. 2020 Jan.

Abstract

Introduction: The present study was conducted to investigate the association between the serum vitamin D levels and severity of disease in chronic rhino sinusitis (CRS) patients.

Materials and methods: This prospective cross-sectional study was conducted on a total of 93 patients suffering from chronic rhino sinusitis with nasal polyposis (CRS w NP). Serum level of 25-hydroxyvitamin D was detected using a simple blood test. A22-item questionnaire, namely the sinonasal outcome test-22 (SNOT-22), was used to assess the subjective disease severity and patients' quality of life. In addition, the radiographic signs of the disease severity were evaluated using the Lund-Mackay Scale (LMS).

Results: The mean age and serum vitamin D level of the patients were measured at 37.7±13.6 years and 24.6±16.9 ng/ml, respectively. Moreover, the mean of LMS and SNOT-22 scores were calculated at 14.2±11.2 and 40.8±17.6, respectively. There was a negative correlation between the SNOT-22 and serum levels of vitamin D (P=0.034). Similarly, LMS and serum vitamin D levels were correlated negatively (P=0.027). Furthermore, the results revealed a direct relationship between LMS and SNOT-22 (P<0.0001).

Conclusion: According to the obtained results, there was a significant relationship between the serum vitamin D levels and severity of disease in patients with CRS w NP. Therefore, serum vitamin D levels could be added to the routine workup of the patients suffering from CRS w NP.

Keywords: CRS w NP; Lund-Mackay Scale; SNOT-22; Vitamin D.

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Figures

Fig1
Fig1
The relationship between SNOT-22 score and serum vitamin D levels
Fig 2
Fig 2
Relationship between the Lund-Mackay score and the serum vitamin D levels.
Fig 3
Fig 3
Correlation between Lund-Mackay and SNOT-22 scores
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References

    1. Tan BK, Schleimer RP, Kern RC. Perspectives on the etiology of chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg. 2010;18(1):21–6. - PMC - PubMed
    1. Kern RC, Conley DB, Walsh W, Chandra R, Kato A, Tripathi-Peters A, et al. Perspectives on the etiology of chronic rhinosinusitis: an immune barrier hypothesis. Am J Rhinol. 2008;22(6):549–59. - PMC - PubMed
    1. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266–81. - PubMed
    1. Wjst M, Hypponen E. Vitamin D serum levels and allergic rhinitis. Allergy. 2007;62(9):1085–6. - PubMed
    1. Zhang N, Van Zele T, Perez-Novo C, Van Bruaene N, Holtappels G, DeRuyck N, et al. Different types of T-effector cells orchestrate mucosal inflammation in chronic sinus disease. J Allergy Clin Immunol. 2008;122(5):961–8. - PubMed

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