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. 2020 May;61(5):662-670.
doi: 10.1002/mus.26840. Epub 2020 Mar 8.

Mechanisms underlying immobilization-induced muscle pain in rats

Satoshi Oga  1   2 , Kyo Goto  3 , Junya Sakamoto  4 , Yuichiro Honda  5 , Ryo Sasaki  1   6 , Kumiko Ishikawa  5 , Hideki Kataoka  3 , Jiro Nakano  4 , Tomoki Origuchi  1 , Minoru Okita  1
Affiliations

Mechanisms underlying immobilization-induced muscle pain in rats

Satoshi Oga et al. Muscle Nerve. 2020 May.

Abstract

Introduction: We investigated the mechanisms underlying immobilization-induced muscle pain in rats.

Methods: In rat skeletal muscle, pressure pain threshold (PPT) of the gastrocnemius muscle was measured, and nerve growth factor (NGF) level, peripheral nerve fiber density, macrophage number, and interleukin-1β (IL-1β) mRNA expression were examined. An NGF receptor inhibitor was injected intramuscularly to assess the relationship between PPT and NGF levels.

Results: Immobilization resulted in a decrease in PPT and increases in NGF level, C-fiber density, M1 macrophage number, and IL-1β mRNA expression. Injection of NGF receptor inhibitor reversed the decrease in PPT.

Discussion: NGF upregulation may be a major contributor to immobilization-induced muscle pain. The increases in C-fiber density, M1 macrophage number, and IL-1β mRNA expression may be related to immobilization-induced muscle pain.

Keywords: C fiber; M1 macrophage; NGF; immobilization; muscle pain.

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References

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