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. 2020 Jun 15;201(12):1575-1578.
doi: 10.1164/rccm.201912-2514LE.

BMP9/10 in Pulmonary Vascular Complications of Liver Disease

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BMP9/10 in Pulmonary Vascular Complications of Liver Disease

Elizabeth R Rochon et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
BMP9 (bone morphogenetic protein 9) and BMP10 levels for hepatopulmonary syndrome (HPS) (n = 80), cirrhotic control subjects (n = 121), portopulmonary hypertension (POPH) (n = 35), and cirrhotic control subjects (n = 186). Lines represent medians, boxes represent interquartile ranges, and whiskers show adjacent values.

References

    1. Fallon MB, Krowka MJ, Brown RS, Trotter JF, Zacks S, Roberts KE, et al. Pulmonary Vascular Complications of Liver Disease Study Group. Impact of hepatopulmonary syndrome on quality of life and survival in liver transplant candidates. Gastroenterology. 2008;135:1168–1175. - PMC - PubMed
    1. Colle IO, Moreau R, Godinho E, Belghiti J, Ettori F, Cohen-Solal A, et al. Diagnosis of portopulmonary hypertension in candidates for liver transplantation: a prospective study. Hepatology. 2003;37:401–409. - PubMed
    1. Tillet E, Ouarné M, Desroches-Castan A, Mallet C, Subileau M, Didier R, et al. A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma. J Biol Chem. 2018;293:10963–10974. - PMC - PubMed
    1. Bidart M, Ricard N, Levet S, Samson M, Mallet C, David L, et al. BMP9 is produced by hepatocytes and circulates mainly in an active mature form complexed to its prodomain. Cell Mol Life Sci. 2012;69:313–324. - PMC - PubMed
    1. David L, Mallet C, Keramidas M, Lamandé N, Gasc JM, Dupuis-Girod S, et al. Bone morphogenetic protein-9 is a circulating vascular quiescence factor. Circ Res. 2008;102:914–922. - PMC - PubMed

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