Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun 15;201(12):1572-1575.
doi: 10.1164/rccm.202001-0089LE.

Risk-stratified Management to Remove Low-Risk Penicillin Allergy Labels in the ICU

Cosby A Stone Jr  1 , Joanna L Stollings  1 , Christopher J Lindsell  1 , Mary Lynn Dear  1 , Reagan B Buie  1 , Todd W Rice  1 , Elizabeth J Phillips  2   3
Affiliations

Risk-stratified Management to Remove Low-Risk Penicillin Allergy Labels in the ICU

Cosby A Stone Jr et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Risk stratification of a historical penicillin reaction. In patients who were already admitted to the ICU, historical reactions consistent with a low-risk penicillin allergy were offered direct challenge with 250 mg oral amoxicillin followed by a 1-hour observation period.
See this image and copyright information in PMC

References

    1. Trubiano JA, Adkinson NF, Phillips EJ. Penicillin allergy is not necessarily forever. JAMA. 2017;318:82–83. - PMC - PubMed
    1. Stone CA, Jr, Trubiano J, Coleman DT, Rukasin CRF, Phillips EJ. The challenge of de-labeling penicillin allergy. Allergy. 2020;75:273–288. - PMC - PubMed
    1. Macy E, Contreras R. Health care use and serious infection prevalence associated with penicillin “allergy” in hospitalized patients: a cohort study. J Allergy Clin Immunol. 2014;133:790–796. - PubMed
    1. MacFadden DR, LaDelfa A, Leen J, Gold WL, Daneman N, Weber E, et al. Impact of reported beta-lactam allergy on inpatient outcomes: a multicenter prospective cohort study. Clin Infect Dis. 2016;63:904–910. - PubMed
    1. Blumenthal KG, Lu N, Zhang Y, Li Y, Walensky RP, Choi HK. Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study. BMJ. 2018;361:k2400. - PMC - PubMed

Publication types