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. 2021 Dec 1;27(8):e302-e306.
doi: 10.1097/RHU.0000000000001350.

Myositis-Specific Antibodies and Myositis-Associated Antibodies in Patients With Idiopathic Inflammatory Myopathies From the PANLAR Myositis Study Group

Yelitza González-Bello, Ignacio Garcia-Valladares  1 , Itzel Viridiana Reyes-Pérez  2 , Daniel García-Cerda  3 , Gabriel Medrano-Ramírez  4 , José E Navarro-Zarza  5 , Lilia Andrade-Ortega  6 , Marco Maradiaga-Ceceña  7 , Alicia Cardenas-Anaya  3 , Arnulfo H Nava-Zavala, Gerardo Orozco-Barocio  3 , Mónica Vázquez-Del Mercado  8 , Armando Rojo-Mejia  9 , Esthela Loyo  10 , Paola Gottschalk  10 , Antonio Iglesias-Gamarra  11 , Kelly Vega  11 , Cilia Rojas  11 , Rubén Mantilla  12 , Graciela Gómez  13 , Abraham García-Kutzbach, Marvin J Fritzler  14 , Ignacio García-De La Torre
Affiliations

Myositis-Specific Antibodies and Myositis-Associated Antibodies in Patients With Idiopathic Inflammatory Myopathies From the PANLAR Myositis Study Group

Yelitza González-Bello et al. J Clin Rheumatol. .

Abstract

Background: Dermatomyositis (DM) and polymyositis (PM) are forms of idiopathic inflammatory myopathies (IIMs), which are associated with the production of autoantibodies that are useful in the diagnosis and prognosis of the disease.

Objective: The aim of this study was to determine the frequency of antinuclear autoantibodies (ANAs), myositis-specific autoantibodies (MSAs), and myositis-associated autoantibodies (MAAs) in 6 Latin American countries.

Methods: Two hundred ten patients with IIM were included in this cross-sectional study from 2014 to 2017: 112 from Mexico, 46 from Colombia, 20 from Peru, 16 from the Dominican Republic, 10 from Argentina, and 6 from Guatemala. Antinuclear autoantibodies were detected by indirect immunofluorescence on HEp-2 cells. MSAs and MAAs were tested by a line immunoassay method. Mann-Whitney U and χ2 tests were used for statistical analysis.

Results: Of the 210 IIM patients, 139 (66.2%) had DM, 59 (28%) PM, and 12 (5.7%) juvenile DM. The mean age was 43.5 (6-79 years); 158 (75.2%) were female, and 52 (24.8%) were male. The overall frequency of ANA was 60%. The most frequent patterns were fine speckled (AC-4) (78.3%) and cytoplasmic (AC-19) (6.45%). The most frequent MSA were anti-Mi-2 (38.5%) and anti-Jo-1 (11.9%). Anti-Mi-2 was more frequent in patients from Colombia (40.1%). The MAA more frequent were anti-Ro-52/TRIM21 (17.6%) and anti-PM-Scl75 (7.5%).

Conclusions: This is the first study of ANA, MSA, and MAA in patients from 6 countries from the Panamerican League against Rheumatism myositis study group. We observed a general prevalence of 60% of ANA. In relation to MSA and MAA, anti-Mi-2 was the more frequent (38.5%).

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Conflict of interest statement

The authors declare no conflict of interest.

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