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. 2020 Feb 20;27(2):137-139.
doi: 10.1016/j.chembiol.2020.02.001.

A Natural Product Puts Malaria on a Low-Fat Diet

Daniel Lucy  1 , Leran Zhang  1 , Edward W Tate  2
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A Natural Product Puts Malaria on a Low-Fat Diet

Daniel Lucy et al. Cell Chem Biol. .
Free article

Abstract

In this issue of Cell Chemical Biology, Yoo et al. (2020) use chemical proteomics to identify target proteins for the potent antimalarial natural product Salinipostin A. Polypharmacology from targeting multiple parasite serine hydrolases and lipases limits resistance to the compound, making this a promising new approach for treating malaria.

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