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Meta-Analysis
. 2020 Mar:161:108087.
doi: 10.1016/j.diabres.2020.108087. Epub 2020 Feb 19.

Cholelithiasis in patients treated with Glucagon-Like Peptide-1 Receptor: An updated meta-analysis of randomized controlled trials

Besmir Nreu  1 , Ilaria Dicembrini  1 , Federico Tinti  1 , Edoardo Mannucci  1 , Matteo Monami  2
Affiliations
Meta-Analysis

Cholelithiasis in patients treated with Glucagon-Like Peptide-1 Receptor: An updated meta-analysis of randomized controlled trials

Besmir Nreu et al. Diabetes Res Clin Pract. 2020 Mar.

Abstract

Glucagon-Like Peptide-1 Receptor Agonists (GLP1-RA) has been associated with cholelithiasis in a previous meta-analysis. The publication of new trials suggests the need for an update. We collected trials with GLP1-RA vs. other therapies, calculating Mantel-Haenszel odds ratio (MH-OR, 95%CI). GLP1-RA significantly increased the risk of cholelithiasis (MH-OR 1.28 [1.11, 1.48]).

Keywords: Glucagon-Like Peptide-1 Receptor Agonists; Meta-analysis.

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