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Review
. 2020 Feb 18;21(4):1382.
doi: 10.3390/ijms21041382.

Autoantibody Biomarkers in Rheumatic Diseases

Eun Ha Kang  1 , You-Jung Ha  1 , Yun Jong Lee  1   2
Affiliations
Review

Autoantibody Biomarkers in Rheumatic Diseases

Eun Ha Kang et al. Int J Mol Sci. .

Abstract

Autoantibodies encountered in patients with systemic rheumatic diseases bear clinical significance as a biomarker to help or predict diagnosis, clinical phenotypes, prognosis, and treatment decision-making. Furthermore, evidence has accumulated regarding the active involvement of disease-specific or disease-associated autoantibodies in the pathogenic process beyond simple association with the disease, and such knowledge has become essential for us to better understand the clinical value of autoantibodies as a biomarker. This review will focus on the current update on the autoantibodies of four rheumatic diseases (rheumatoid arthritis, myositis, systemic sclerosis, and anti-neutrophil cytoplasmic antibody associated vasculitis) where there has been a tremendous progress in our understanding on their biological effects and clinical use.

Keywords: autoantibody; biomarker; rheumatic disease.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Pathogenic roles of antineutrophil cytoplasmic antibodies (ANCAs).
See this image and copyright information in PMC

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