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Comment
. 2020 Apr;10(4):484.
doi: 10.1158/2159-8290.CD-ND2020-004. Epub 2020 Feb 21.

Cancer Immunotherapy: Make Way for CAR NK

No authors listed
Comment

Cancer Immunotherapy: Make Way for CAR NK

No authors listed. Cancer Discov. 2020 Apr.

Abstract

Having shown preclinical promise, the first clinical data are now in on natural killer cells equipped with a chimeric antigen receptor targeting CD19. Albeit in a small number of patients so far, the experimental immunotherapy has elicited a high response rate with little to no toxicity.

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  • Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors.
    Liu E, Marin D, Banerjee P, Macapinlac HA, Thompson P, Basar R, Nassif Kerbauy L, Overman B, Thall P, Kaplan M, Nandivada V, Kaur I, Nunez Cortes A, Cao K, Daher M, Hosing C, Cohen EN, Kebriaei P, Mehta R, Neelapu S, Nieto Y, Wang M, Wierda W, Keating M, Champlin R, Shpall EJ, Rezvani K. Liu E, et al. N Engl J Med. 2020 Feb 6;382(6):545-553. doi: 10.1056/NEJMoa1910607. N Engl J Med. 2020. PMID: 32023374 Free PMC article. Clinical Trial.

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