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Case Reports
. 2020 May;189(3):e100-e103.
doi: 10.1111/bjh.16512. Epub 2020 Feb 22.

Major surgery management in patients with haemophilia A and inhibitors on emicizumab prophylaxis without global coagulation monitoring

Christine Biron-Andreani  1   2 , Isabelle Diaz-Cau  2 , Alexandre Ranc  2 , Robert Navarro  1 , Christian Leonardi  3 , Marion Dischino  3 , Romuald Guy  4 , Alexandre Theron  1 , Corinne Garcia-Gournay  1   2 , Elena Santagostino  5 , Jean-François Schved  2
Affiliations
Case Reports

Major surgery management in patients with haemophilia A and inhibitors on emicizumab prophylaxis without global coagulation monitoring

Christine Biron-Andreani et al. Br J Haematol. 2020 May.
No abstract available

Keywords: emicizumab; haemophilia A; inhibitors; major surgery.

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References

    1. Abshire, T. & Kenet, G. (2008) Safety update on the use of recombinant factor VIIa and the treatment of congenital and acquired deficiency of factor VIII or IX with inhibitors. Haemophilia, 14, 898-902.
    1. Collins, P.W., Liesne, R., Makris, M., Talks, K., Chowdary, P., Chalmers, E., Hall, G., Riddell, A., Percy, C.L., Hay, C.R. & Hart, D.P. (2018) Treatment of bleeding episodes in haemophilia A complicated by a factor VIII inhibitor in patients receiving Emicizumab. Interim guidance from UKHCDO Inhibitor Working Party and Executive Committee. Haemophilia, 24, 344-347.
    1. Dargaud, Y., Lienhart, A., Janbain, M., Le Quellec, S., Enjolras, N. & Négrier, C. (2018) Use of thrombin generation assay to personalize treatment of breakthrough bleeds in a patient with hemophilia and inhibitors receiving prophylaxis with emicizumab. Haematologica, 103, e181-e183.
    1. Giangrande, P.L.F., Hermans, C., O’Mahony, B., de Kleijn, P., Bedford, M., Batorova, A., Blatný, J., Jansone, K.; European Haemophilia Consortium (EHC) and the European Association for Haemophilia and Allied Disorders (EAHAD). (2018) European principles of inhibitor management in patients with haemophilia. Orphanet Journal of Rare Diseases, 13, 66.
    1. Kizilocak, H., Yukhtman, C.L., Marquez-Casas, E., Lee, J., Donkin, J. & Young, G. (2019) Management of perioperative hemostasis in a severe hemophilia A patient with inhibitors on emicizumab using global hemostasis assays. Therapeutic Advances in Hematology, 10, 1-9.

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