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Comparative Study
. 1988 Dec 1;7(12):3737-43.
doi: 10.1002/j.1460-2075.1988.tb03257.x.

A new type of transforming growth factor-beta, TGF-beta 3

R Derynck  1 , P B Lindquist, A Lee, D Wen, J Tamm, J L Graycar, L Rhee, A J Mason, D A Miller, R J Coffey, et al.
Affiliations
Comparative Study

A new type of transforming growth factor-beta, TGF-beta 3

R Derynck et al. EMBO J. .

Abstract

A new type of TGF-beta, TGF-beta 3, has been identified by cDNA characterization. The amino acid sequence of mature TGF-beta 3 and its precursor has been derived from porcine and human cDNA sequences. The human TGF-beta 3 gene is spread over seven exons as in the case of the TGF-beta 1 gene. Comparison with TGF-beta 1 and -beta 2 indicates a strong conservation of the mature sequences, but a relaxed homology in the precursor segments. TGF-beta 3 mRNA is mainly expressed in cell lines from mesenchymal origin, suggesting a biological role different from the other TGFs-beta.

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