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. 1988 Dec 1;7(12):3873-9.
doi: 10.1002/j.1460-2075.1988.tb03273.x.

The Xenopus laevis mitochondrial protein mtDBP-C cooperatively folds the DNA in vitro

B Mignotte  1 , E Delain, D Rickwood, M Barat-Gueride
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The Xenopus laevis mitochondrial protein mtDBP-C cooperatively folds the DNA in vitro

B Mignotte et al. EMBO J. .

Abstract

The binding of the Xenopus laevis mitochondrial protein mtDBP-C to DNA was studied by equilibrium density banding, agarose gel electrophoresis and electron microscopy. The results obtained show that the mtDBP-C binds cooperatively to DNA irrespective of whether the DNA is supercoiled, relaxed or linear and it induces the formation of superhelical turns locally leading to the formation of a highly folded structure. It appears that this protein could be involved in the compaction of DNA in the mitochondrial nucleoid.

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