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Review
. 2020 Jan 31:2020:7593402.
doi: 10.1155/2020/7593402. eCollection 2020.

Dental Stem Cell-Derived Secretome/Conditioned Medium: The Future for Regenerative Therapeutic Applications

Sara El Moshy  1   2 , Israa Ahmed Radwan  1   2 , Dina Rady  1   2 , Marwa M S Abbass  1   2 , Aiah A El-Rashidy  2   3 , Khadiga M Sadek  2   3 , Christof E Dörfer  4 , Karim M Fawzy El-Sayed  2   4   5
Affiliations
Review

Dental Stem Cell-Derived Secretome/Conditioned Medium: The Future for Regenerative Therapeutic Applications

Sara El Moshy et al. Stem Cells Int. .

Abstract

Regenerative medicine literature has proposed mesenchymal stem/progenitor cell- (MSC-) mediated therapeutic approaches for their great potential in managing various diseases and tissue defects. Dental MSCs represent promising alternatives to nondental MSCs, owing to their ease of harvesting with minimally invasive procedures. Their mechanism of action has been attributed to their cell-to-cell contacts as well as to the paracrine effect of their secreted factors, namely, secretome. In this context, dental MSC-derived secretome/conditioned medium could represent a unique cell-free regenerative and therapeutic approach, with fascinating advantages over parent cells. This article reviews the application of different populations of dental MSC secretome/conditioned medium in in vitro and in vivo animal models, highlights their significant implementation in treating different tissue' diseases, and clarifies the significant bioactive molecules involved in their regenerative potential. The analysis of these recent studies clearly indicate that dental MSCs' secretome/conditioned medium could be effective in treating neural injuries, for dental tissue regeneration, in repairing bone defects, and in managing cardiovascular diseases, diabetes mellitus, hepatic regeneration, and skin injuries, through regulating anti-inflammatory, antiapoptotic, angiogenic, osteogenic, and neurogenic mediators.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

References

    1. Atala A. Advances in tissue and organ replacement. Current Stem Cell Research & Therapy. 2008;3(1):21–31. doi: 10.2174/157488808783489435. - DOI - PubMed
    1. Berthiaume F., Maguire T. J., Yarmush M. L. Tissue engineering and regenerative medicine: history, progress, and challenges. Annual Review of Chemical and Biomolecular Engineering. 2011;2(1):403–430. doi: 10.1146/annurev-chembioeng-061010-114257. - DOI - PubMed
    1. Stoltz J.-F., de Isla N., Li Y. P., et al. Stem cells and regenerative medicine: myth or reality of the 21th century. Stem Cells International. 2015;2015:19. doi: 10.1155/2015/734731.734731 - DOI - PMC - PubMed
    1. Gao G., Cui X. Three-dimensional bioprinting in tissue engineering and regenerative medicine. Biotechnology Letters. 2016;38(2):203–211. doi: 10.1007/s10529-015-1975-1. - DOI - PubMed
    1. Guan X., Avci‐Adali M., Alarçin E., et al. Development of hydrogels for regenerative engineering. Biotechnology Journal. 2017;12(5, article 1600394) doi: 10.1002/biot.201600394. - DOI - PMC - PubMed

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