Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jan 24:11:8.
doi: 10.4103/ijpvm.IJPVM_541_17. eCollection 2020.

Effects of Probiotic Soy Milk Fermented by Lactobacillus plantarum A7 (KC 355240) added with Cuminum Cyminum Essential Oil on Fasting Blood Glucose Levels, Serum Lipid Profile and Body Weight in Diabetic Wistar Rats

Mina Babashahi  1 , Maryam Mirlohi  2 , Reza Ghiasvand  3 , Leila Azadbakht  3 , Laleh Mosharaf  4 , Sahar Torki-Baghbadorani  2
Affiliations

Effects of Probiotic Soy Milk Fermented by Lactobacillus plantarum A7 (KC 355240) added with Cuminum Cyminum Essential Oil on Fasting Blood Glucose Levels, Serum Lipid Profile and Body Weight in Diabetic Wistar Rats

Mina Babashahi et al. Int J Prev Med. .

Abstract

Background: There is some separate evidence that probiotic soy milk and Cuminum cyminum (C. cyminum) have positive effects on the prevention and reduction of diabetic complications. While the impact of probiotic soymilk mixed with herbal essential oils has not been investigated so far, the objective of this study is to examine the effects of probiotic soy milk using Lactobacillus plantarum A7 (KC 355240) added with essential oil of C. cyminum on diabetic rats.

Methods: 50 streptozotocin-nicotinamide (STZ-NA) induced diabetic Wistar rats were divided into five groups: Control group (C group), soy milk group (SM group), probiotic soy milk group (PSM group), soy milk containing essential oil of C. cyminum group (SMC group) and probiotic soy milk containing essential oil of C. cyminum group (PSMC group). The animals consumed these products (1 ml/day) for 30 days. The fasting blood glucose (FBS), the serum lipid levels, and body weight variation were analyzed in 10-day intervals.

Results: FBS, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) decreased significantly, whereas high-density lipoprotein cholesterol (HDL-C) increased in the PSMC group compared with that of other groups (P < 0.05). This product also led to weight gain (P < 0.05).

Conclusions: A mixture of probiotic soy milk and herbal essential oil consumption could impose a positive effect on reducing FBS as well as serum lipid profile in STZ- NA diabetes-induced rat. Also, it results in an increase in their weight gain.

Keywords: Cuminum cyminum; Lactobacillus plantarum A7; diabetic; soy milk.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Body weight (g) in the treatment groups at 10 day intervals. C = Control; SM = Soy milk; PSM = Probiotic soy milk; SMC = Soy milk containing essential oil of C. cyminum; PSMC = Probiotic soy milk containing essential oil of C. cyminum. Values are presented as Mean ± SEM. aP < 0.05 vs. control in the same time. bP < 0.05 vs. SM group in the same time. cP < 0.05 vs. PSM group in the same time. *P < 0.05 vs. baseline in the same group
See this image and copyright information in PMC

References

    1. American diabetes association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37:81–90.
    1. Guariguata L, Whiting D, Hambleton I, Beagley J, Linnenkamp U, Shaw J. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 2014;103:137–49. - PubMed
    1. Zhang P, Zhang X, Brown J, Vistisen D, Sicree R, Shaw J, et al. Global healthcare expenditure on diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010;87:293–301. - PubMed
    1. Liu ZM, Chen YM, Ho SC. Effects of soy intake on glycemic control: A meta-analysis of randomized controlled trials. Am J Clin Nutr. 2011;93:1092–101. - PubMed
    1. Ju HE, Han JS. Hypoglycemic Effect of Fermented Soymilk Added with Bokbunja (Rubus coreanus Miquel) in Diabetic Mice. Food Sci Biotechnol. 2010;19:1041–6.