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Review
. 2020 Feb 10:9:F1000 Faculty Rev-101.
doi: 10.12688/f1000research.20867.1. eCollection 2020.

New technologies to analyse protein function: an intrinsic disorder perspective

Vladimir N Uversky  1   2
Affiliations
Review

New technologies to analyse protein function: an intrinsic disorder perspective

Vladimir N Uversky. F1000Res. .

Abstract

Functions of intrinsically disordered proteins do not require structure. Such structure-independent functionality has melted away the classic rigid "lock and key" representation of structure-function relationships in proteins, opening a new page in protein science, where molten keys operate on melted locks and where conformational flexibility and intrinsic disorder, structural plasticity and extreme malleability, multifunctionality and binding promiscuity represent a new-fangled reality. Analysis and understanding of this new reality require novel tools, and some of the techniques elaborated for the examination of intrinsically disordered protein functions are outlined in this review.

Keywords: intrinsically disordered protein; intrinsically disordered protein region; protein function; structure-function continuum.

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Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

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