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Randomized Controlled Trial
. 2020 Mar;28(3):537-543.
doi: 10.1002/oby.22728.

Association Between Lifestyle and Hypertriglyceridemic Waist Phenotype in the PREDIMED-Plus Study

José Carlos Fernández-García #  1   2 , Araceli Muñoz-Garach #  1   2 , Miguel Ángel Martínez-González  2   3   4 , Jordi Salas-Salvado  2   5   6   7 , Dolores Corella  2   8 , Álvaro Hernáez  2   9   10 , Dora Romaguera  2   11 , Jesús Vioque  12   13 , Ángel M Alonso-Gómez  2   14   15 , Julia Wärnberg  2   16 , J Alfredo Martínez  2   17   18 , Luís Serra-Majem  2   19 , Ramón Estruch  2   9   20 , José Lapetra  2   21 , Xavier Pintó  2   20   22 , Josep A Tur  2   23 , Antonio Garcia-Rios  2   24 , Laura García Molina  12   25 , José Juan Gaforio  12   26 , Pilar Matía-Martín  27 , Lidia Daimiel  28 , Vicente Martín Sánchez  12   29 , Josep Vidal  30   31 , Lucia Prieto  32 , Emilio Ros  2   33 , Nuria Goñi  2   3 , Nancy Babio  2   5   6   7 , Carolina Ortega-Azorin  2   8 , Olga Castañer  2   34 , Jadwiga Konieczna  2   11 , Leyre Notario Barandiaran  12   13 , Jessica Vaquero-Luna  2   14 , Juan Carlos Benavente-Marín  2   16 , M Angeles Zulet  2   17 , Almudena Sanchez-Villegas  2   19 , Emilio Sacanella  2   9   20 , Ricardo Gómez Huelgas  2   35 , Leticia Miró-Moriano  2   21 , Mariano Gimenez-Gracia  2   22 , Alicia Julibert  2   11   23 , Cristina Razquin  2   3   4 , Josep Basora  5   7 , Olga Portolés  2   8 , Albert Goday  20   34 , Aina M Galmés-Panadés  2   11 , Carmen M López-García  36 , Anai Moreno-Rodriguez  2   14 , Estefanía Toledo  2   3   4 , Andrés Díaz-López  2   5   6   7 , Montserrat Fitó  2   34 , Francisco J Tinahones  1   2 , M Rosa Bernal-López  2   35 ; PREDIMED-Plus Investigators
Affiliations
Randomized Controlled Trial

Association Between Lifestyle and Hypertriglyceridemic Waist Phenotype in the PREDIMED-Plus Study

José Carlos Fernández-García et al. Obesity (Silver Spring). 2020 Mar.

Abstract

Objective: The hypertriglyceridemic waist (HTGW) phenotype is characterized by abdominal obesity and high levels of triglycerides. In a cross-sectional assessment of PREDIMED-Plus trial participants at baseline, HTGW phenotype prevalence was evaluated, associated risk factors were analyzed, and the lifestyle of individuals with metabolic syndrome and HTGW was examined.

Methods: A total of 6,874 individuals aged 55 to 75 with BMI ≥ 27 and < 40 kg/m2 were included and classified by presence (HTGW+ ) or absence (HTGW- ) of HTGW (waist circumference: men ≥ 102 cm, women ≥ 88 cm; fasting plasma triglycerides ≥ 150 mg/dL). Analytical parameters and lifestyle (energy intake and expenditure) were analyzed.

Results: A total of 38.2% of the sample met HTGW+ criteria. HTGW+ individuals tended to be younger, have a greater degree of obesity, be sedentary, and be tobacco users. They had higher peripheral glucose, total cholesterol, and low-density lipoprotein cholesterol levels; had lower high-density lipoprotein cholesterol levels; and had increased prevalence of type 2 diabetes mellitus. Mediterranean diet (MedDiet) adherence and physical activity were greater in HTGW- patients. Age, BMI, tobacco use, total energy expenditure, hypertension, type 2 diabetes mellitus, and MedDiet adherence were associated with HTGW+ .

Conclusions: HTGW is a highly prevalent phenotype in this population associated with younger age, higher BMI, tobacco use, and decreased MedDiet adherence. HTGW- individuals were more physically active with greater total physical activity, and fewer had hypertension.

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References

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