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Review

Buruli Ulcer in Japan

Koichi Suzuki  1 , Yuqian Luo  1 , Yuji Miyamoto  2 , Chiaki Murase  3 , Mariko Mikami-Sugawara  4   5 , Rie R. Yotsu  6 , Norihisa Ishii  2
Gerd Pluschke  1 , Katharina Röltgen  2
, editors.
In: Buruli Ulcer: Mycobacterium Ulcerans Disease [Internet]. Cham (CH): Springer; 2019.
.
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Review

Buruli Ulcer in Japan

Koichi Suzuki et al.
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Excerpt

Buruli ulcer (BU) is not endemic to Japan, but 60 cases have been reported since 1982. The causative bacterium is Mycobacterium ulcerans subsp. shinshuense, which appears to be unique to Japan and potentially China. Genetic characterization of this species has begun, and the efficacy of various therapies has been analyzed. Although treatment with triple antimicrobial therapy comprising rifampicin (RFP; 450 mg/day), levofloxacin (LVFX; 500 mg/day), and clarithromycin (CAM; 800 mg/day) seemed to be effective in Japanese BU cases, establishment of a standard diagnosis and treatment guideline optimized for BU infections in Japan and other Asian countries is needed. Furthermore, a comprehensive comparison of the proteomes of M. ulcerans subsp. shinshuense with classical M. ulcerans may clarify the differences in their adaptive biology and response to antibiotic treatment. Because of the distinctive four seasons in Japan, there is a clear seasonal variation in the occurrence of BU and possibly of the number of bacteria in the environment. Therefore, although there are not many cases of BU in Japan, studying them will shed light on the bacteriological and clinical aspects of BU.

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References

    1. Mikoshiba H, Shindo Y, Matsumoto H et al (1982) A case of typical mycobacteriosis due to Mycobacterium ulcerans-like organism (in Japanese). Jpn J Dermatol 92(5):557–565 - PubMed
    1. Tsukamura M, Kaneda K, Imaeda T et al (1989) A taxonomic study on a mycobacterium which caused a skin ulcer in a Japanese girl and resembled Mycobacterium ulcerans. Kekkaku 64(11):691–697 - PubMed
    1. Kazumi Y, Ohtomo K, Takahashi M et al (2004) Mycobacterium shinshuense isolated from cutaneous ulcer lesion of right lower extremity in a 37-year-old woman (in Japanese). Kekkaku 79(7):437–441 - PubMed
    1. Nakanaga K, Ishii N, Suzuki K et al (2007) “Mycobacterium ulcerans subsp. shinshuense” isolated from a skin ulcer lesion: identification based on 16S rRNA gene sequencing. J Clin Microbiol 45(11):3840–3843. https://doi.org/10.1128/JCM.01041-07 - DOI - PMC - PubMed
    1. Yotsu RR, Nakanaga K, Hoshino Y et al (2012) Buruli ulcer and current situation in Japan: a new emerging cutaneous Mycobacterium infection. J Dermatol 39(7):587–593. https://doi.org/10.1111/j.1346-8138.2012.01543.x - DOI - PubMed

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