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Review

Acute Lymphoblastic Leukemia in Children and Adolescents

Christina Peters  1 , Franco Locatelli  2   3 , Peter Bader  4
Enric Carreras  1 , Carlo Dufour  2 , Mohamad Mohty  3 , Nicolaus Kröger  4
, editors.
In: The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies [Internet]. 7th edition. Cham (CH): Springer; 2019. Chapter 72.
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Review

Acute Lymphoblastic Leukemia in Children and Adolescents

Christina Peters et al.
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Excerpt

Although the majority of children and adolescents with acute lymphoblastic leukemia (ALL) are curable with current chemotherapy regimens, poor outcome persists in some individuals (Eckert et al. 2011; von Stackelberg et al. 2011; Schrappe et al. 2012).

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References

    1. Bader P, Kreyenberg H, Henze GH, et al. Prognostic value of minimal residual disease quantification before allogeneic stem-cell transplantation in relapsed childhood acute lymphoblastic leukemia: the ALL-REZ BFM Study Group. J Clin Oncol. 2009;27:377–84. - PubMed
    1. Bader P, Kreyenberg H, von Stackelberg A, et al. Monitoring of minimal residual disease after allogeneic stem-cell transplantation in relapsed childhood acute lymphoblastic leukemia allows for the identification of impending relapse: results of the ALL-BFM-SCT 2003 trial. J Clin Oncol. 2015;33:1275–84. - PubMed
    1. Berger M, Lanino E, Cesaro S, et al. Feasibility and outcome of haploidentical hematopoietic stem cell transplantation with post-transplant high-dose cyclophosphamide for children and adolescents with hematologic malignancies: an AIEOP-GITMO Retrospective Multicenter Study. Biol Blood Marrow Transplant. 2016;22:902–9. - PubMed
    1. Bernt KM, Hunger SP. Current concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia. Front Oncol. 2014;4:54. - PMC - PubMed
    1. Boztug H, Zecca M, Sykora KW, et al. EBMT paediatric diseases working party. Treosulfan-based conditioning regimens for allogeneic HSCT in children with acute lymphoblastic leukemia. Ann Hematol. 2015;94:297–306. - PubMed

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