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Review

Primary Immunodeficiencies

Michael Albert  1 , Arjan Lankester  2 , Andrew Gennery  3
Enric Carreras  1 , Carlo Dufour  2 , Mohamad Mohty  3 , Nicolaus Kröger  4
, editors.
In: The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies [Internet]. 7th edition. Cham (CH): Springer; 2019. Chapter 89.
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Review

Primary Immunodeficiencies

Michael Albert et al.
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Excerpt

Primary immunodeficiency (PID) diseases arise from genetic defects that lead to abnormalities in immune cell development or function with a wide spectrum in severity and clinical manifestations.

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References

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    1. Aiuti A, Biasco L, Scaramuzza S, et al. Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome. Science. 2013;341:1233151. - PMC - PubMed
    1. Albert MH, Hauck F, Wiebking V, et al. Allogeneic stem cell transplantation in adolescents and young adults with primary immunodeficiencies. J Allergy Clin Immunol Pract. 2018;6:298–301. - PubMed
    1. Antoine C, Müller S, Cant A, European Group for Blood and Marrow Transplantation; European Society for Immunodeficiency, et al. Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968-99. Lancet. 2003;361:553–60. - PubMed
    1. Balashov D, Shcherbina A, Maschan M, et al. Single-center experience of unrelated and haploidentical stem cell transplantation with TCRαβ and CD19 depletion in children with primary immunodeficiency syndromes. Biol Blood Marrow Transplant. 2015;21:1955–62. - PubMed

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