Polygenic Risk Scores and Coronary Artery Disease: Ready for Prime Time?

Michael G Levin^{1

2}, Daniel J Rader^{2

3}

Affiliations

¹ Division of Cardiovascular Medicine (M.G.L.), University of Pennsylvania Perelman School of Medicine, Philadelphia.
² Department of Medicine (M.G.L., D.J.R.), University of Pennsylvania Perelman School of Medicine, Philadelphia.
³ Department of Genetics (D.J.R.), University of Pennsylvania Perelman School of Medicine, Philadelphia.

Editorial

Michael G Levin et al. Circulation. 2020.

. 2020 Feb 25;141(8):637-640.

doi: 10.1161/CIRCULATIONAHA.119.044770. Epub 2020 Feb 24.

Michael G Levin^{1

2}, Daniel J Rader^{2

3}

¹ Division of Cardiovascular Medicine (M.G.L.), University of Pennsylvania Perelman School of Medicine, Philadelphia.
² Department of Medicine (M.G.L., D.J.R.), University of Pennsylvania Perelman School of Medicine, Philadelphia.
³ Department of Genetics (D.J.R.), University of Pennsylvania Perelman School of Medicine, Philadelphia.

No abstract available

Keywords: Editorials; coronary artery disease; genome-wide association study; risk assessment.

Comment on

Patients With High Genome-Wide Polygenic Risk Scores for Coronary Artery Disease May Receive Greater Clinical Benefit From Alirocumab Treatment in the ODYSSEY OUTCOMES Trial.
Damask A, Steg PG, Schwartz GG, Szarek M, Hagström E, Badimon L, Chapman MJ, Boileau C, Tsimikas S, Ginsberg HN, Banerjee P, Manvelian G, Pordy R, Hess S, Overton JD, Lotta LA, Yancopoulos GD, Abecasis GR, Baras A, Paulding C; Regeneron Genetics Center and the ODYSSEY OUTCOMES Investigators. Damask A, et al. Circulation. 2020 Feb 25;141(8):624-636. doi: 10.1161/CIRCULATIONAHA.119.044434. Epub 2019 Nov 11. Circulation. 2020. PMID: 31707832 Clinical Trial.
Predicting Benefit From Evolocumab Therapy in Patients With Atherosclerotic Disease Using a Genetic Risk Score: Results From the FOURIER Trial.
Marston NA, Kamanu FK, Nordio F, Gurmu Y, Roselli C, Sever PS, Pedersen TR, Keech AC, Wang H, Lira Pineda A, Giugliano RP, Lubitz SA, Ellinor PT, Sabatine MS, Ruff CT. Marston NA, et al. Circulation. 2020 Feb 25;141(8):616-623. doi: 10.1161/CIRCULATIONAHA.119.043805. Epub 2019 Nov 11. Circulation. 2020. PMID: 31707849 Free PMC article. Clinical Trial.