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. 2021 Mar 26;10(2):213-216.
doi: 10.1093/jpids/piaa014.

Identification of an Emergent Pathogen, Bartonella vinsonii, Using Next-Generation Sequencing in a Patient With Culture-Negative Endocarditis

Rachel D Downey  1 , Susan M Russo  1 , Sarmistha B Hauger  1   2 , Donald K Murphey  1   2 , Grace Marx  3 , Thanhthao Huynh  4 , Amy M Denison  4 , Rachel Quirt  1 , Ann Bailey  1 , Marisol Fernandez  1   2
Affiliations

Identification of an Emergent Pathogen, Bartonella vinsonii, Using Next-Generation Sequencing in a Patient With Culture-Negative Endocarditis

Rachel D Downey et al. J Pediatric Infect Dis Soc. .

Abstract

Diagnosis and treatment of culture negative endocarditis remains a challenge. This report describes a rare cause of endocarditis in humans, Bartonella vinsonii, identified through next generation sequencing of plasma microbial cell-free DNA with confirmation of cardiac valve tissue infection through immunohistochemical staining and polymerase chain reaction.

Keywords: Bartonella vinsonii; diagnostics; endocarditis; glomerulonephritis; next-generation sequencing.

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Conflict of interest statement

Potential conflicts of interest. All authors: No potential conflicts of interest.

All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

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MeSH terms

Supplementary concepts