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Comparative Study
. 2020 Apr;80(4):469-496.
doi: 10.1016/j.jinf.2020.02.013. Epub 2020 Feb 21.

Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV

Rui Li  1 , Songlin Qiao  1 , Gaiping Zhang  2
Affiliations
Comparative Study

Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV

Rui Li et al. J Infect. 2020 Apr.
No abstract available

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Conflict of interest statement

Declaration of Competing Interest The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Sequence alignment of ACE2 from human (UniProt entry Q9BYF1), Northern white-cheeked gibbon (UniProt entry G1RE79), green monkey (UniProt entry A0A0D9RQZ0), crab-eating macaque (UniProt entry A0A2K5X283), Sumatran orangutan (UniProt entry Q5RFN1), chimpanzee (UniProt entry A0A2J8KU96), cat (UniProt entry Q56H28), dog (UniProt entry J9P7Y2), bovine (UniProt entry Q58DD0), sheep (UniProt entry W5PSB6), goat (UniProt entry A0A452EVJ5), swine (UniProt entry K7GLM4), horse (UniProt entry F6V9L3), ferret (UniProt entry Q2WG88), civet (UniProt entry Q56NL1), Chinese horseshoe bat (UniProt entry E2DHI7), mouse (UniProt entry Q8R0I0) and rat (UniProt entry Q5EGZ1). (A) Region 30–41. (B) Region 82–84. (C) Region 353–357. The conserved residues in the regions are colored in red and the critical residues are marked by asterisks.
Fig. 2
Fig. 2
Structural analyses of the human ACE2 (PDB code 2AJF) with the modeled mouse (A) and rat (B) ones in cartoon diagrams and surface electrostatic potential maps. The regions 30–41, 82–84 and 353–357 are enlarged and the critical residues are labeled. The changed ones affecting the electrostatic potential are labeled and circled in dashed lines. The electrostatic potential is colored from −62 to +62 kiloteslas/charge.
See this image and copyright information in PMC

Comment in

References

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