Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 May-Jun;22(4-5):172-181.
doi: 10.1016/j.micinf.2020.02.001. Epub 2020 Feb 21.

The immunopathogenesis of tuberculous pericarditis

Patrick Howlett  1 , Elsa Du Bruyn  2 , Hazel Morrison  3 , Isiguzo C Godsent  4 , Katalin A Wilkinson  5 , Mpiko Ntsekhe  2 , Robert J Wilkinson  6
Affiliations
Free article
Review

The immunopathogenesis of tuberculous pericarditis

Patrick Howlett et al. Microbes Infect. 2020 May-Jun.
Free article

Abstract

Tuberculous pericarditis is a severe form of extrapulmonary tuberculosis and is the commonest cause of pericardial effusion in high incidence settings. Mortality ranges between 8 and 34%, and it is the leading cause of pericardial constriction in Africa and Asia. Current understanding of the disease is based on models derived from studies performed in the 1940-50s. This review summarises recent advances in the histology, microbiology and immunology of tuberculous pericarditis, with special focus on the effect of Human Immunodeficiency Virus (HIV) and the determinants of constriction.

Keywords: Constriction; HIV; Immunology; Pathogenesis; Pericardial; Tuberculosis.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing interest The authors have no conflict of interest to declare.

Publication types

MeSH terms

LinkOut - more resources