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Comment
. 2020 Feb 24;24(1):63.
doi: 10.1186/s13054-020-2801-2.

In severe liver disease, citrate can be used safely: the question remains-by which mechanism

Affiliations
Comment

In severe liver disease, citrate can be used safely: the question remains-by which mechanism

Patrick M Honore et al. Crit Care. .
No abstract available

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Conflict of interest statement

The authors declare that they have no competing interests.

Comment on

References

    1. Zhang W, Bai M, Yu Y, Li L, Zhao L, Sun S, Chen X. Safety and efficacy of regional citrate anticoagulation for continuous renal replacement therapy in liver failure patients: a systematic review and meta-analysis. Crit Care. 2019;23(1):22. doi: 10.1186/s13054-019-2317-9. - DOI - PMC - PubMed
    1. Khadzhynov D, Schelter C, Lieker I, Mika A, Staeck O, Neumayer HH, et al. Incidence and outcome of metabolic disarrangements consistent with citrate accumulation in critically ill patients undergoing continuous venovenous hemodialysis with regional citrate anticoagulation. J Crit Care. 2014;29(2):265–271. doi: 10.1016/j.jcrc.2013.10.015. - DOI - PubMed
    1. Klingele M, Stadler T, Fliser D, Speer T, Groesdonk HV, Raddatz A. Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction. Crit Care. 2017;21:294. doi: 10.1186/s13054-017-1870-3. - DOI - PMC - PubMed
    1. Honore PM, De Bels D, Redant S, Attou R, Kugener L, Boer W. Inducible metabolic pathway for citrate metabolism in case of major liver dysfunction: fact or fiction? Crit Care. 2019;23(1):166. doi: 10.1186/s13054-019-2432-7. - DOI - PMC - PubMed
    1. Slowinski T, Morgera S, Joannidis M, Henneberg T, Stocker R, Helset E, et al. Safety and efficacy of regional citrate anticoagulation in continuous venovenous hemodialysis in the presence of liver failure: the liver citrate anticoagulation threshold (L-CAT) observational study. Crit Care. 2015;19:349. doi: 10.1186/s13054-015-1066-7. - DOI - PMC - PubMed