Liver Kinase B1 (LKB1) Loss Has its p-ERKs: ERK Inactivation as a Vulnerability in NSCLC With LKB1 Mutations

Affiliations

¹ Program in Solid Tumors, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.
² Program in Solid Tumors, Center for Applied Medical Research, University of Navarra, Pamplona, Spain; Department of Biochemistry and Genetics, University of Navarra, Pamplona, Spain.
³ Program in Solid Tumors, Center for Applied Medical Research, University of Navarra, Pamplona, Spain; Department of Biochemistry and Genetics, University of Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.
⁴ Program in Solid Tumors, Center for Applied Medical Research, University of Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain; Navarra Institute for Health Research, University of Navarra, Pamplona, Spain; Department of Pathology, Anatomy, and Physiology, Pamplona, Spain. Electronic address: silvevicent@unav.es.

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Irati Macaya et al. J Thorac Oncol. 2020 Mar.

Free article

. 2020 Mar;15(3):311-313.

doi: 10.1016/j.jtho.2019.11.017.

¹ Program in Solid Tumors, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.
² Program in Solid Tumors, Center for Applied Medical Research, University of Navarra, Pamplona, Spain; Department of Biochemistry and Genetics, University of Navarra, Pamplona, Spain.
³ Program in Solid Tumors, Center for Applied Medical Research, University of Navarra, Pamplona, Spain; Department of Biochemistry and Genetics, University of Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain.
⁴ Program in Solid Tumors, Center for Applied Medical Research, University of Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain; Navarra Institute for Health Research, University of Navarra, Pamplona, Spain; Department of Pathology, Anatomy, and Physiology, Pamplona, Spain. Electronic address: silvevicent@unav.es.

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LKB1 Deficiency Renders NSCLC Cells Sensitive to ERK Inhibitors.
Caiola E, Iezzi A, Tomanelli M, Bonaldi E, Scagliotti A, Colombo M, Guffanti F, Micotti E, Garassino MC, Minoli L, Scanziani E, Broggini M, Marabese M. Caiola E, et al. J Thorac Oncol. 2020 Mar;15(3):360-370. doi: 10.1016/j.jtho.2019.10.009. Epub 2019 Oct 18. J Thorac Oncol. 2020. PMID: 31634668