Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Apr:219:263-266.e1.
doi: 10.1016/j.jpeds.2019.11.035. Epub 2020 Feb 21.

Reverse Sequence Syphilis Screening and Discordant Results in Pregnancy

Jessica E P Williams  1 , José A Bazan  2 , Abigail Norris Turner  3 , Stephen F Thung  4 , Cory Hanlon  5 , Tanisha R Pettus  6 , Pablo J Sánchez  7
Affiliations

Reverse Sequence Syphilis Screening and Discordant Results in Pregnancy

Jessica E P Williams et al. J Pediatr. 2020 Apr.

Abstract

A "reverse sequence syphilis screening" algorithm is widely used for syphilis testing. This retrospective study showed that most (65%) pregnant women with discordant screening results (treponemal multiplex flow immunoassay IgG+/rapid plasma reagin-) had a nonreactive confirmatory Treponema pallidum-particle agglutination assay, likely indicative of a false-positive reaction.

Keywords: congenital syphilis; maternal syphilis; reverse syphilis screening.

PubMed Disclaimer

Publication types