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Review
. 2020 Jan 28:16:39-54.
doi: 10.2147/TCRM.S232033. eCollection 2020.

Uric Acid and Arterial Stiffness

Adriana Albu  1 , Ioana Para  2 , Mihai Porojan  1
Affiliations
Review

Uric Acid and Arterial Stiffness

Adriana Albu et al. Ther Clin Risk Manag. .

Abstract

Hyperuricemia is usually associated with hypertension, diabetes mellitus, metabolic syndrome and chronic kidney disease. Accumulating data from epidemiological studies indicate an association of increased uric acid (UA) with cardiovascular diseases. Possible pathogenic mechanisms include enhancement of oxidative stress and systemic inflammation caused by hyperuricemia. Arterial stiffness may be one of the possible pathways between hyperuricemia and cardiovascular disease, but a clear relationship between increased UA and vascular alterations has not been confirmed. The review summarizes the epidemiological studies investigating the relationship between UA and arterial stiffness and highlights the results of interventional studies evaluating arterial stiffness parameters in patients treated with UA-lowering drugs.

Keywords: arterial stiffness; cardiovascular risk; uric acid.

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Conflict of interest statement

The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Mechanisms involved in uric acid induced arterial stiffness. XO, xanthine oxidase; ROS, reactive oxygen species; URATv1, voltage- driven urate efflux transporter 1; NLRP3,nod-like receptor family protein 3; VSMCs, vascular smooth muscle cells.
See this image and copyright information in PMC

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