Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Nov 15;5(12):e507.
doi: 10.1097/TXD.0000000000000936. eCollection 2019 Dec.

Comparison of a Behavioral Versus an Educational Weight Management Intervention After Renal Transplantation: A Randomized Controlled Trial

Gabriela Schmid-Mohler  1   2 , Patrizia Zala  2 , Nicole Graf  3 , Patrick Witschi  2 , Thomas F Mueller  2 , Rudolf Peter Wüthrich  2 , Laura Huber  1 , Thomas Fehr  2   4 , Rebecca Spirig  5
Affiliations

Comparison of a Behavioral Versus an Educational Weight Management Intervention After Renal Transplantation: A Randomized Controlled Trial

Gabriela Schmid-Mohler et al. Transplant Direct. .

Abstract

Background: In the first year following renal transplantation, preventing weight gain to minimize overweight or obesity is particularly important. The aim of this study is to test the effect of an 8-month behavioral intervention BMI and physical activity.

Methods: This randomized controlled study included 123 adult kidney or kidney-pancreas recipients. Patients were randomized to usual (1 educational session, then weight self-monitoring) and intervention care (usual care plus 7-8 counseling sessions). Alongside weight, body composition, and physical activity, satisfaction and perceptions regarding care were measured at weeks 2-6 (baseline), then at months 8 and 12.

Results: Both groups reported comparably high satisfaction. The intervention group (IG) reported more chronic care-related activities. In patients with BMIs ≥ 18.5, mean weight gain (from baseline) was unexpectedly low in both groups: at month 8, +0.04 kg/m2 in IG patients and +0.14 kg/m2 in the control group (P = 0.590), and respectively, +0.03 kg/m2 and +0.19 kg/m2 at month 12 (P = 0.454). Both groups were physically active, walking averages of 10 807 (IG) and 11 093 (control group) steps per day at month 8 (P = 0.823), and respectively 9773 and 11 217 at month 12 (P = 0.195).

Conclusions: The behavioral intervention had high patient acceptance and supported patients in maintaining their weight, but had no superior effect on a single educational session. Further research is needed to assess patient weight gain risk profiles to stratify the intervention.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1.
FIGURE 1.
Timeline of measurements, randomization, and interventions.
FIGURE 2.
FIGURE 2.
Study flow chart.
FIGURE 3.
FIGURE 3.
BMI at baseline, month 8 and 12, stratified by treatment group and baseline BMI. Error bars show mean and 95% confidence interval. Number of patients.
FIGURE 4.
FIGURE 4.
LTI at baseline, month 8 and 12, stratified by treatment group and gender. Error bars show mean and 95% confidence interval. LTI, lean tissue index.
FIGURE 5.
FIGURE 5.
Waist-to-hip ratio at baseline, month 8 and 12, stratified by treatment group and gender. Error bars show mean and 95% confidence interval.
FIGURE 6.
FIGURE 6.
Number of steps at month 8 and 12, stratified by intensity. Error bars show mean and 95% confidence interval.
FIGURE 7.
FIGURE 7.
IPAQ METs at baseline, month 8 and 12, stratified by intensity. Error bars show mean and 95% confidence interval. MET, metabolic equivalent of task.
See this image and copyright information in PMC

References

    1. Kasiske BL, Zeier MG, Chapman JR, et al. ; Kidney Disease: Improving Global Outcomes KDIGO clinical practice guideline for the care of kidney transplant recipients: a summary. Kidney Int 201077299–311 - PubMed
    1. Beckmann S, Nikolic N, Denhaerynck K, et al. Evolution of body weight parameters up to 3 years after solid organ transplantation: the prospective Swiss Transplant Cohort Study. Clin Transplant 2017311–11 - PubMed
    1. Zelle DM, Kok T, Dontje ML, et al. The role of diet and physical activity in post-transplant weight gain after renal transplantation. Clin Transplant 201327E484–E490 - PubMed
    1. Lafranca JA, IJermans JN, Betjes MG, et al. Body mass index and outcome in renal transplant recipients: a systematic review and meta-analysis. BMC Med. 2015;13:111. - PMC - PubMed
    1. Bundesamt für Gesundheit, Bundesamt für Statistik. Schweizerische Gesundheitsbefragung 2012: Übergewicht und Adipositas. Neuchatel, Switzerland: Federal Office of Public Health (FOPH); 2014.