Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Nov;41(11):1191-5.
doi: 10.1136/jcp.41.11.1191.

HMFG-2 as a prognostic indicator in superficial bladder cancer

I G Conn  1 , J Crocker, L A Emtage, D M Wallace
Affiliations

HMFG-2 as a prognostic indicator in superficial bladder cancer

I G Conn et al. J Clin Pathol. 1988 Nov.

Abstract

A series of transitional cell carcinomas and mucosal biopsy specimens of bladder were stained immunohistochemically with the monoclonal antibody HMFG-2. Staining characteristics ranged from luminal staining in well differentiated, superficial lesions to staining of all cells in invasive carcinomas. Invasive tumour nests also stained strongly with the antibody. There was good correlation between the staining pattern and histological assessment of both tumours and mucosal biopsy specimens. Correlation with clinical course showed that it was also a good predictor of subsequent disease progression of superficial tumours. It is suggested that HMFG-2 staining is a sensitive indictor of malignant transformation and that it may have a role as an adjunct to conventional histological examination in the assessment of urothelial carcinomas.

PubMed Disclaimer

References

    1. Lancet. 1974 Nov 30;2(7892):1290-2 - PubMed
    1. Br J Cancer. 1985 Sep;52(3):355-61 - PubMed
    1. J Clin Pathol. 1979 Jan;32(1):35-9 - PubMed
    1. J Clin Pathol. 1979 Oct;32(10):971-8 - PubMed
    1. Cancer. 1981 Jan 1;47(1):104-12 - PubMed

Publication types