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. 2021 Jan;27(1):94-110.
doi: 10.1111/odi.13312. Epub 2020 Mar 19.

What is the optimal timing for implant placement in oral cancer patients? A scoping literature review

Jamie M Alberga  1 , Nathalie Vosselman  1 , Anke Korfage  1 , Konstantina Delli  1 , Max J H Witjes  1 , Gerry M Raghoebar  1 , Arjan Vissink  1
Affiliations

What is the optimal timing for implant placement in oral cancer patients? A scoping literature review

Jamie M Alberga et al. Oral Dis. 2021 Jan.

Abstract

Background: Oral cancer patients can benefit from dental implant placement. Traditionally, implants are placed after completing oncologic treatment (secondary implant placement). Implant placement during ablative surgery (primary placement) in oral cancer patients seems beneficial in terms of early start of oral rehabilitation and limiting additional surgical interventions. Guidelines on the ideal timing of implant placement in oral cancer patients are missing.

Objective: To perform a scoping literature review on studies examining the timing of dental implant placement in oral cancer patients and propose a clinical practice recommendations guideline.

Methods: A literature search for studies dealing with primary and/or secondary implant placement in MEDLINE was conducted (last search December 27, 2019). The primary outcome was 5-year implant survival.

Results: Sixteen out of 808 studies were considered eligible. Both primary and secondary implant placement showed acceptable overall implant survival ratios with a higher pooled 5-year implant survival rate for primary implant placement 92.8% (95% CI: 87.1%-98.5%) than secondary placed implants (86.4%, 95% CI: 77.0%-95.8%). Primary implant placement is accompanied by earlier prosthetic rehabilitation after tumor surgery.

Conclusion: Patients with oral cancer greatly benefit from, preferably primary placed, dental implants in their prosthetic rehabilitation. The combination of tumor surgery with implant placement in native mandibular bone should be provided as standard care.

Keywords: ablative surgery; dental implants; dental prosthesis; head and neck cancer; primary placement; timing.

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Conflict of interest statement

The authors have stated explicitly that there are no conflicts of interest in connection with this article.

Figures

Figure 1
Figure 1
Timing of oncologic treatment and oral rehabilitation
Figure 2
Figure 2
Flowchart of study selection procedure
Figure 3
Figure 3
Forest plot for cumulative weighted 5‐year implant survival rate for primary implant placement
Figure 4
Figure 4
Forest plot for cumulative weighted 5‐year implant survival rate for secondary implant placement
Figure 5
Figure 5
Recommendations for dental implant placement to support implant‐retained overdentures in head and neck cancer patients. *Includes zygoma implants
See this image and copyright information in PMC

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References

    1. Awad, M. E. , Altman, A. , Elrefai, R. , Shipman, P. , Looney, S. , & Elsalanty, M. (2019). The use of vascularized fibula flap in mandibular reconstruction; A comprehensive systematic review and meta‐analysis of the observational studies. Journal of Cranio‐Maxillo‐Facial Surgery, 47, 629–641. - PubMed
    1. Barber, A. J. , Butterworth, C. J. , & Rogers, S. N. (2011). Systematic review of primary osseointegrated dental implants in head and neck oncology. British Journal of Oral and Maxillofacial Surgery, 49, 29–36. 10.1016/j.bjoms.2009.12.007 - DOI - PubMed
    1. Bodard, A. G. , Salino, S. , Bemer, J. , Lucas, R. , & Breton, P. (2011). Dental implant placement after mandibular reconstruction by microvascular free fibula flap: Current knowledge and remaining questions. Oral Oncology, 47, 1099–1104. - PubMed
    1. Buddula, A. , Assad, D. A. , Salinas, T. J. , Garces, Y. I. , Volz, J. E. , & Weaver, A. L. (2012). Survival of dental implants in irradiated head and neck cancer patients: A retrospective analysis. Clinical Implant Dentistry and Related Research, 14(5), 716–722. 10.1111/j.1708-8208.2010.00307.x - DOI - PubMed
    1. Butterworth, C. J. (2019). Primary vs secondary zygomatic implant placement in patients with head and neck cancer – A 10‐year prospective study. Head & Neck, 41, 1687–1695. 10.1002/hed.245645 - DOI - PubMed

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