MEIOSIN: A New Watchman of Meiotic Initiation in Mammalian Germ Cells
- PMID: 32097650
- PMCID: PMC8555863
- DOI: 10.1016/j.devcel.2020.02.002
MEIOSIN: A New Watchman of Meiotic Initiation in Mammalian Germ Cells
Abstract
The capacity to undergo meiosis defines vertebrate germ cells, yet mechanisms driving initiation of this specialized process are largely undefined. In this issue of Developmental Cell,Ishiguro et al. (2020) identified the transcription factor MEIOSIN as a gatekeeper of meiotic initiation in both male and female germ cells.
Copyright © 2020 Elsevier Inc. All rights reserved.
Comment on
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MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells.Dev Cell. 2020 Feb 24;52(4):429-445.e10. doi: 10.1016/j.devcel.2020.01.010. Epub 2020 Feb 6. Dev Cell. 2020. PMID: 32032549
References
-
- Baltus AE, Menke DB, Hu YC, Goodheart ML, Carpenter AE, de Rooij DG, and Page DC (2006). In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication. Nat. Genet 38, 1430–1434. - PubMed
-
- Bowles J, Knight D, Smith C, Wilhelm D, Richman J, Mamiya S, Yashiro K, Chawengsaksophak K, Wilson MJ, Rossant J, et al. (2006). Retinoid signaling determines germ cell fate in mice. Science 312, 596–600. - PubMed
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- Ishiguro KI, Matsuura K, Tani N, Takeda N, Usuki S, Yamane M, Sugimoto M, Fujimura S, Hosokawa M, Chuma S, et al. (2020). MEIOSIN directs the switch from mitosis to meiosis in mammalian germ cells. Dev. Cell 52, this issue, 429–445. - PubMed
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