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Review
. 2019 Dec 31:12:953-959.
doi: 10.2147/CCID.S189000. eCollection 2019.

Inverse Psoriasis: From Diagnosis to Current Treatment Options

Giuseppe Micali  1 , Anna Elisa Verzì  1 , Giorgia Giuffrida  1 , Enrico Panebianco  1 , Maria Letizia Musumeci  1 , Francesco Lacarrubba  1
Affiliations
Review

Inverse Psoriasis: From Diagnosis to Current Treatment Options

Giuseppe Micali et al. Clin Cosmet Investig Dermatol. .

Abstract

Inverse psoriasis represents a clinical variant of psoriasis that is sometimes difficult to diagnose due to its clinical similarity with other skin disorders involving the folds, mainly including mechanical intertrigo, fungal and bacterial infections, contact dermatitis, seborrheic dermatitis, and lichen planus. Dermoscopy represents a useful tool for an enhanced non-invasive diagnosis. The treatment of inverse psoriasis may be challenging and include topical corticosteroids, topical calcineurin inhibitors, vitamin D analogs, traditional oral systemic therapies such as cyclosporine and methotrexate, and biologic therapies.

Keywords: confocal microscopy; dermoscopy; diagnosis; inverse; psoriasis; treatment.

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Conflict of interest statement

Maria Letizia Musumeci reports personal fees from Abbvie, personal fees from Biogen, personal fees from Janssen Cilag, personal fees from Eli Lilly, personal fees from Novartis, outside the submitted work. The authors report no other conflicts of interest in this work.

Figures

Figure 1
Figure 1
Inverse psoriasis of the inframammary folds in a 38-year-old woman: well demarcated, erythematous patches with fine scaling.
Figure 2
Figure 2
Inverse psoriasis of the perianal area in a 54-year-old woman: symmetrical, erythematous patch with minimal scaling.
Figure 3
Figure 3
Inverse psoriasis of the right axilla in an infant: minimal erythematosus patch.
Figure 4
Figure 4
Inverse psoriasis of the right popliteal fossa in a 5-year-old child: moist, shiny, erythematous patches.
Figure 5
Figure 5
Inverse psoriasis of the right inguinal fold in 46-year-old man (A); x10 dermoscopy shows homogeneously distributed “red dots” on an erythematous background (B); x150 dermoscopy shows typical “bushy” capillaries.
Figure 6
Figure 6
Diagnostic flow-chart of inverse psoriasis.
See this image and copyright information in PMC

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