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Review
. 2020 Feb 4:13:39-49.
doi: 10.2147/PGPM.S205079. eCollection 2020.

Towards Precision Medicine in Systemic Lupus Erythematosus

Elliott Lever  1 , Marta R Alves  2 , David A Isenberg  1
Affiliations
Review

Towards Precision Medicine in Systemic Lupus Erythematosus

Elliott Lever et al. Pharmgenomics Pers Med. .

Abstract

Systemic lupus erythematosus (SLE) is a remarkable condition characterised by diversity amongst its clinical features and immunological abnormalities. In this review, we attempt to capture the major immunological changes linked to the pathophysiology of lupus and discuss the challenge it presents in moving towards the concept of precision medicine. Currently broadly similar types of drugs, e.g., steroids, immunosuppressives, hydroxychloroquine are used to treat many of the diverse clinical features of SLE. We suspect that, as the precise immunopathological abnormalities differ between the various organs/systems in lupus patients, it will be some time before precision medicine can be fully applied to SLE.

Keywords: anti-DNA antibodies; immunosuppression; lupus genetics; lupus nephritis; systemic lupus erythematosus.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

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