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. 1988 Nov;235(8):466-71.
doi: 10.1007/BF00314249.

Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease

P Foley  1 , H F Bradford, M Docherty, H Fillit, V N Luine, B McEwen, G Bucht, B Winblad, J Hardy
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Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease

P Foley et al. J Neurol. 1988 Nov.

Abstract

A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data presented support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.

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