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. 2020 Feb 25;12(4):3911-3925.
doi: 10.18632/aging.102859. Epub 2020 Feb 25.

Subjective cognitive decline detected by the oscillatory connectivity in the default mode network: a magnetoencephalographic study

Chia-Hsiung Cheng  1   2   3   4 , Pei-Ning Wang  5   6   7 , Hui-Fen Mao  8   9 , Fu-Jung Hsiao  5
Affiliations

Subjective cognitive decline detected by the oscillatory connectivity in the default mode network: a magnetoencephalographic study

Chia-Hsiung Cheng et al. Aging (Albany NY). .

Abstract

Discriminating between those with and without subjective cognitive decline (SCD) in cross-sectional investigations using neuropsychological tests is challenging. The available magnetoencephalographic (MEG) studies have demonstrated altered alpha-band spectral power and functional connectivity in those with SCD. However, whether the functional connectivity in other frequencies and brain networks, particularly the default mode network (DMN), exhibits abnormalities in SCD remains poorly understood. We recruited 26 healthy controls (HC) without SCD and 27 individuals with SCD to perform resting-state MEG recordings. The power of each frequency band and functional connectivity within the DMN were compared between these two groups. Posterior cingulate cortex (PCC)-based connectivity was also used to test its diagnostic accuracy as a predictor of SCD. There were no significant between-group differences of spectral power in the regional nodes. However, compared with HC, those with SCD demonstrated increased delta-band and gamma-band functional connectivity within the DMN. Moreover, node strength in the PCC exhibited a good discrimination ability at both delta and gamma frequencies. Our data suggest that the node strength of delta and gamma frequencies in the PCC may be a good neurophysiological marker in the discrimination of individuals with SCD from those without SCD.

Keywords: delta oscillation; functional connectivity; gamma oscillation; resting state; subjective memory complaint.

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Conflict of interest statement

CONFLICTS OF INTEREST: The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Upper panel: The intrinsic functional connectivity of default mode network viewed from the left and right side. Lower panel: Node strength of each brain area from delta to gamma2 bands was color-coded for healthy controls (HC) and individuals with subjective cognitive decline (SCD). The difference (HC minus SCD) of the node strength demonstrated the alterations of functional connectivity due to SCD. *p < 0.05.
Figure 2
Figure 2
The significant differences regarding the functional connectivity between healthy controls (HC) and individuals with subjective cognitive decline (SCD). In the delta (A) and gamma1 (B) oscillations, SCD showed significantly stronger functional connectivity between posterior cingulate cortex and precuneus, and between posterior cingulate cortex and lateral temporal cortex. In the gamma2 oscillations (C), SCD showed significantly stronger functional connectivity between posterior cingulate cortex and precuneus. *p < 0.05, **p < 0.01.
Figure 3
Figure 3
Receiver operating characteristic curves of delta, gamma1 and gamma2 frequency bands for the discrimination of healthy controls from individuals with subjective cognitive decline.
Figure 4
Figure 4
Procedures of resting-state MEG data analysis.
Figure 5
Figure 5
Selected regions of interest within the default mode network and the corresponding MNI coordinates.
See this image and copyright information in PMC

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